Diprotin A - CAS:90614-48-5

您当前的位置：

Diprotin A (Synonyms:Ile-Pro-Ile;抑二肽素A)

目录号 : KCM15691 CAS No. : 90614-48-5 纯度 : ≥98%

Data Sheet SDS 产品使用指南

Diprotin A is a tripeptide inhibitor of dipeptidyl peptidase 4 (DPP-4; IC = 1.1 μg/ml). It inhibits degradation of glucagon-like peptide 1 (GLP-1; ) in culture with insulin-secreting BRIN-BD11 rat pancreatic β-cells when used at a concentration of 25 μM. Diprotin A (5 mg/ml) pre-incubation enhances chemotaxis of murine embryonic stem cells towards stromal cell-derived factor-1 (SDF-1/CXCL12) in vitro. Pre-incubation of CD34 human umbilical cord blood cells with diprotin A (5 mM) prior to injection increases engraftment in NOD/SCID recipient mice.

规格	价格	是否有货	数量
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

Begelomab In-stock
Diprotin A In-stock
Nateglinide-d5 (phenyl-d5) In-stock
Gly-Pro-pNA (hydrochloride) In-stock
Vildagliptin In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

Diprotin A is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

IC₅₀&Target

DPP-4

体外研究

Diprotin A (100 μ M; 30 minutes after treatment with CXCR4 blocker or Src inhibitor) induces phosphorylation of Src [Tyr 416] and VE cadherin [Tyr731] in hEC under normoxic and H/R conditions in human endothelial cells, and disrupts CXCR4 (SDF-1 α receptor) blockade or Src inhibitor to weaken endothelial cell junctions.

Western Blot Analysis

Cell Line:	Human endothelial cells
Concentration:	100 μM
Incubation Time:	30 minutes after CXCR4-blocker or Src-inhibitor treatment
Result:	Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs.

体内研究

Diprotin A (100 μM; 30 minutes after treatment with CXCR4 blocker or Src inhibitor) induces phosphorylation of Src [Tyr 416] and VE cadherin [Tyr731] in hEC under normoxic and H/R conditions in human endothelial cells, and disrupts CXCR4 (SDF-1 α receptor) blockade or Src inhibitor to weaken endothelial cell junctions.

Animal Model:

Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice

Dosage:

70 μg/kg

Administration:

Intraperitoneal injection; twice daily; 7 days

Result:

Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.

分子式

C₁₇H₃₁N₃O₄

分子量

341.45

CAS号

90614-48-5

中文名称

抑二肽素A

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light, under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month sealed storage, away from moisture and light, under nitrogen)

溶解性数据

In Vitro:

H2O : ≥ 100 mg/mL (292.87 mM)

DMSO : 100 mg/mL (292.87 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9287 mL	14.6434 mL	29.2869 mL
5 mM	0.5857 mL	2.9287 mL	5.8574 mL
10 mM	0.2929 mL	1.4643 mL	2.9287 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

SDS

产品使用指南

Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation

动物实验计算换算器