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Apoptosis——PKD

PKD (Protein kinase D) is an evolutionarily conserved protein kinase family with structural, enzymological, and regulatory properties different from the PKC family members. Signaling through PKD is induced by a remarkable number of stimuli, including G-protein-coupled receptor agonists and polypeptide growth factors. PKD family of serine/threonine protein kinases has three members: PKD1, PKD2, PKD3. PKD1, the most studied member of the family, is increasingly implicated in the regulation of a complex array of fundamental biological processes, including signal transduction, cell proliferation and differentiation, membrane trafficking, secretion, immune regulation, cardiac hypertrophy and contraction, angiogenesis, and cancer. PKD mediates such a diverse array of normal and abnormal biological functions via dynamic changes in its spatial and temporal localization, combined with its distinct substrate specificity.

Apoptosis——PKD(5)

Cat. No.	Product Name	CAS No.	Purity
KM10358	CID 2011756 CID 2011756 是一种广谱的，ATP 竞争性的 PKD 抑制剂，对 PKD1 的 IC₅₀ 值为 3.2 µM，在细胞中对 PKD2 和 PKD3 的 IC₅₀ 值分别为 0.6 和 0.7 µM；CID 2011756 同时具有抗肿瘤活性。	638156-11-3	96%
KM4093	CID755673 CID755673是高效选择性的PKD1抑制剂，IC₅₀* of 值为182 nM。*	521937-07-5	98%
KE9528	CRT0066101	956121-30-5	≥95%
KM7142	CRT0066101 dihydrochloride CRT0066101 dihydrochloride是有效，选择性的 PKD* 抑制剂，对PKD1，2和3的IC₅₀值分别为1，2.5和2 nM。*	1883545-60-5	98%
KM8643	kb NB 142-70 kb NB 142-70 是一种有效的 PKD* 抑制剂，对 PKD1，PKD2 和 PKD3 的 IC₅₀ 值分别为 28.3 nM，58.7 nM 和 53.2 nM；kb NB 142-70 同时具有抗肿瘤活性。*	1233533-04-4	98%