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Apoptosis——Pyroptosis

Pyroptosis is a type of programmed cell death that features pore formation on the plasma membrane, cell swelling and plasma membrane disruption. Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation.

Gasdermin D (GSDMD), as the executive protein of pyroptosis, is activated and transferred to the membrane to induce glial rupture, resulting in the release of more inflammatory mediators.

Inflammasome is an intracellular signaling complex of the innate immune system. Activation of inflammasomes promotes the secretion of IL-1β/IL-18 and triggers pyroptosis. The proinflammatory effect of IL-1β/IL-18 and pyroptosis contributes to the development of autoimmune and inflammatory diseases.

Apoptosis——Pyroptosis(12)

Cat. No. Product Name CAS No. Purity Chemical Structure
KM22003 7DG 26927-01-5
KM21997 8α-Tigloyloxyhirsutinolide 13-O-acetate 83182-58-5
KM22000 Ac-FEID-CMK
KM22001 Ac-FEID-CMK TFA
KM9719 Ac-FLTD-CMK

Ac-FLTD-CMK 是胃泌素 D (GSDMD) 衍生的抑制剂,是炎症性 caspases 的特异性抑制剂。Ac-FLTD-CMK 对 caspases-1 (IC50 为 46.7 nM),caspases-4 (IC50 为 1.49 μM),caspases-5 (IC50 为 329 nM) 和 caspases-11 均有效,但对凋亡相关的 caspase-3 无效。

2376255-48-8 99%
KE3080 antcin A 163597-24-8 ≥95%
KM12553 Disulfiram

Disulfiram (Tetraethylthiuram disulfide) 是特异性的乙醛脱氢酶 1 型抗体 (ALDH1) 抑制剂,对酒精具有急性敏感性。Disulfiram 有效抑制人体和小鼠细胞中脂质体中的 GSDMD 孔形成,炎性体介导的细胞凋亡和 IL-1β 分泌。

97-77-8 97%
KM21999 ICy-Q
KM6378 LDC7559

LDC7559 是一种 消皮素 D (GSDMD) 的抑制剂,通过抑制中性粒细胞胞外杀菌网络 (NET) 后期阶段而发挥作用。

2407782-01-6 99%
KM15438 Morroniside

Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用。

25406-64-8 98%
KM22002 NLRP3/AIM2-IN-2 791840-86-3
KM18760 Polyphyllin VI

Polyphyllin VI,一种活性皂甙,具有抗癌活性。Polyphyllin VI 诱导 G2/M 细胞周期停滞并引发细胞凋亡。Polyphyllin VI 通过诱导非小细胞肺癌中的 ROS/NF-κB/NLRP3/GSDMD 信号轴来诱导 caspase-1 介导的细胞焦亡 (pyroptosis)。

55916-51-3 98%
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