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Cell Cycle/DNA Damage——DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

Cell Cycle/DNA Damage——DNA Alkylator/Crosslinker(58)

Cat. No. Product Name CAS No. Purity Chemical Structure
KM4308 (S)-Seco-Duocarmycin SA

(S)-Seco-Duocarmycin SA 是一种 DNA 烷化剂 (DNA alkylator),可作为抗体药物偶联物的毒素部分 (ADC cytotoxin) 起作用。

152785-82-5 ≥99%
KM6018 4-Hydroperoxy cyclophosphamide

4-Hydroperoxy cyclophosphamide 是前药 Cyclophosphamide 的活性代谢产物形式。4-Hydroperoxy cyclophosphamide 交联 DNA,诱导 T 细胞不依赖于死亡受体激活的凋亡,可以通过产生活性氧 (ROS) 激活线粒体死亡途径。4-Hydroperoxy cyclophosphamide 有潜力用于淋巴瘤和自身免疫性疾病的研究。

39800-16-3 ≥98%
KM10782 4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d4 是 4-Hydroperoxy cyclophosphamide 的氘代物。4-Hydroperoxy cyclophosphamide 是前药 Cyclophosphamide 的活性代谢产物形式。4-Hydroperoxy cyclophosphamide 交联 DNA,诱导 T 细胞不依赖于死亡受体激活的凋亡,可以通过产生活性氧 (ROS) 激活线粒体死亡途径。4-Hydroperoxy cyclophosphamide 有潜力用于淋巴瘤和自身免疫性疾病的研究。

1246816-71-6
KM19385 Altretamine

Altretamine 是一种烷化剂 (alkylator),具有抗肿瘤活性。

645-05-6 99%
KM19164 Bendamustine hydrochloride

Bendamustine hydrochloride (SDX-105),一种嘌呤类似物,是一种 DNA 交联剂。Bendamustine hydrochloride 可激活 DNA 损伤反应和细胞凋亡 (apoptosis)。Bendamustine hydrochloride 具有有效的烷基化,抗癌和抗代谢作用。

3543-75-7 98%
KM12823 Busulfan

Busulfan是一种有效的烷化剂,对骨髓具有选择性免疫抑制作用。

55-98-1 ≥98%
KM15565 Calicheamicin

Calicheamicin 是一种肿瘤抗生素,也是有效的细胞毒性试剂,可引起DNA双链断裂。Calicheamicin 抑制 DNA 合成。

108212-75-5 98%
KM12653 Carboplatin

Carboplatin (NSC 241240) 是一种 DNA 合成 抑制剂,其与 DNA 结合,抑制复制和转录并诱导细胞死亡。Carboplatin (NSC 241240) 是顺铂的衍生物,是一种有效的抗癌剂。

41575-94-4 ≥98%
KM9312 Carmustine

Carmustine 是一种抗肿瘤化疗剂,为 DNARNA 的烷化剂 (alkylator)。

154-93-8 99%
KM4168 Chlorambucil

Chlorambucil 是一种口服抗肿瘤活性剂和双功能烷基化剂 (alkylating agent),属于氮芥类。Chlorambucil 可用于研究淋巴细胞白血病、卵巢癌和乳腺癌以及霍奇金病。

305-03-3 98%
KM16283 Cisplatin

Cisplatin (CDDP) 是一种抗肿瘤的化疗剂,它与 DNA 交联引起癌细胞中 DNA 损伤。Cisplatin 可激活铁死亡 (ferroptosis) 并诱导自噬 (autophagy)。

15663-27-1 ≥99%
KM11921 Cyclophosphamide

Cyclophosphamide 是一种合成的 DNA Alkylator,在化学上与氮芥类有关,具有抗肿瘤及免疫抑制活性。

50-18-0 ≥98%
KM15911 Cyclophosphamide hydrate

Cyclophosphamide hydrate 是一种合成的 DNA Alkylator,在化学上与氮芥类有关,具有抗肿瘤及免疫抑制活性。

6055-19-2 ≥98%
KM7928 Duocarmycin Analog

Duocarmycin Analog 是 Duocarmycin 的类似物,可用作 DNA 烷化剂 (DNA alkylator) 和 抗体偶联药物 (ADC cytotoxin) 的毒素部分。

372954-15-9
KM9027 Duocarmycin DM free base

Duocarmycin DM free base 是一种 DNA 小沟烷基化剂 (DNA minor-groove alkylator),是一种抗体药物结合物 (ADCs) 毒素。Duocarmycin DM free base 因特有的结构而具有抗癌活性。

1116745-06-2
KM20356 Duocarmycin MA 1613286-57-9
KM3517 Duocarmycin MB

Duocarmycin MB 是抗体偶联药物 (ADCs) 中的毒素分子。Duocarmycin 是一种 DNA 烷化剂,靶向 DNA 小沟。Duocarmycin MB 可用于抗多药耐药细胞系。

1613286-58-0
KM10084 Duocarmycin TM

Duocarmycin TM 是一种非常有效的有抗肿瘤活性的抗生素。Duocarmycin TM 是一种 DNA 烷化剂。

157922-77-5 98%
KM16461 Ifosfamide

Ifosfamide 是一种烷化剂 (DNA alkylator),具有广谱的抗肿瘤作用。

3778-73-2 ≥98%
KM9032 Illudin M

Illudin M 是一种细胞毒性真菌倍半萜,可以从 Omphalotus olearius 蘑菇培养基中分离得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗肿瘤活性。

1146-04-9
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