Telomerase is a DNA polymerase that extends the 3' ends of chromosomes by processively synthesizing multiple telomeric repeats. It is a unique ribonucleoprotein (RNP) containing a specialized telomerase reverse transcriptase (TERT) and telomerase RNA (TER) with its own template and other elements required with TERT for activity (catalytic core), as well as species-specific TER-binding proteins important for biogenesis and assembly (core RNP); other proteins bind telomerase transiently or constitutively to allow association of telomerase and other proteins with telomere ends for regulation of DNA synthesis.
Telomerase activity is responsible for the maintenance of chromosome end structures (telomeres) and cancer cell immortality in most human malignancies, making telomerase an attractive therapeutic target. Indeed, a telomerase inhibitor is expected to provide a therapeutic benefit in most cancers while having little side-effects. The adult stem cells that express telomerase in normal tissues divide slowly and have long telomeres, therefore they should be less impacted by telomerase inhibition than the cancer cells which divide rapidly and usually possess short telomeres.
| Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| KM6658 |
360A iodide
360A iodide 是一种 G-四联体 (G-quadruplex) 的稳定剂，同时可抑制端粒酶 (telomerase) 的活性，在 TRAP-G4 实验中，IC50 值为 300 nM。 |
737763-37-0 | ≥98% |
|
| KM12332 |
BIBR 1532
BIBR 1532 是一种有效的，选择性的 telomerase 非竞争性抑制剂，IC50 值为 100 nM。 |
321674-73-1 | 98% |
|
| KM4534 |
Ceramides Mixture
Ceramides Mixture 是一种内源性神经酰胺，由含羟基和非羟基脂肪酸的神经酰胺组成。Ceramides Mixture 是表皮渗透屏障的主要脂质成分。Ceramides Mixture 参与生长抑制，细胞周期停滞和端粒酶 (telomerase) 活性的调节。 |
100403-19-8 | ≥98% |
|
| KM15373 |
Cycloastragenol
Cycloastragenol (Astramembrangenin) 是 astragaloside IV的活性形式，具有抗氧化、抗炎、抗衰老、抗凋亡和心血管保护作用。Cycloastragenol是一种有效的端粒酶 (telomerase) 激活剂，可以延长端粒。Cycloastragenol 缓解与年龄相关的骨丢失，改善骨微结构和生物力学特性。 |
78574-94-4 | ≥98% |
|
| KM15475 |
Epitalon
Epitalon 是一种抗衰老剂和端粒酶激活剂。Epitalon 对小鼠自发性肿瘤的发展具有抑制作用，具有 geroprotective 作用，通过鼻内给药可增加神经元活性。Epitalon 可用于癌症，衰老和色素性视网膜炎。 |
307297-39-8 |
|
|
| KM15470 |
Epitalon TFA
Epitalon TFA 是一种抗衰老剂和端粒酶激活剂。Epitalon TFA 对小鼠自发性肿瘤的发展具有抑制作用，具有 geroprotective 作用，通过鼻内给药可增加神经元活性。Epitalon TFA 可用于癌症，衰老和色素性视网膜炎。 |
98% |
|
|
| KM6952 |
MST-312
MST-312 是一个 telomerase 抑制剂。MST-312 是绿茶表没食子儿茶素没食子酸酯 (EGCG) 的化学修饰衍生物。MST-312 可用于肿瘤的研究，如多发性骨髓瘤 (MM)。 |
368449-04-1 | 98% |
|
| KM5333 |
RHPS4
RHPS4 是有效的端粒酶 (telomerase) 抑制剂 (IC50 = 0.33 μM)。RHPS4 是 DNA 损伤的诱导剂。 |
390362-78-4 | 98% |
|
| KE7340 | Telomerase-IN-1 | 666859-49-0 | ≥95% |
|
| KM7017 |
Telomerase-IN-2
Telomerase-IN-2 是一种端粒酶 (telomerase) 抑制剂，通过降低角化不良蛋白的表达来抑制其活性，IC50 值为 0.89 µM。Telomerase-IN-2 具有抗癌作用。 |
1610878-54-0 | 98% |
|
| KM3947 |
TMPyP4 tosylate
TMPyP4 tosylate (TMP 1363) 是一种四链体 (G-quadruplex) 特异性配体，可抑制 G-四链体和 IGF-1 之间的相互作用。TMPyP4 tosylate (TMP 1363) 是一种端粒酶 (telomerase) 抑制剂，在骨肉瘤细胞系中具有抗肿瘤作用。 |
36951-72-1 | ≥98% |
|
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