MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM).
IC50&Target
telomeras
体外研究
MST-312 (2~8 μM; 0~72 hours; U-266 cells) reduces cellular viability in a dose dependent and time-dependent manner.
MST-312 (2~8 μM; 48 hours; U-266 cells) induces cell apoptosis in a dose-dependent manner.
MST-312 (2 μM; 48 hours; U-266 cells) up-regulates the pro-apoptotic gene Bax and down-regulates the anti-apoptotic gene Bcl-2 and suppresses the expression of c-Myc and hTERT genes.
Cell Viability Assay
Cell Line:
U-266 cells
Concentration:
2~8 μM
Incubation Time:
0~72 hours
Result:
The viability of U-266 cells was substantially decreased in a dose dependent and time-dependent manner, in response to exposure to MST-312.
Apoptosis Analysis
Cell Line:
U-266 cells
Concentration:
2~8 μM
Incubation Time:
48 hours
Result:
Induced cell apoptosis in a dose-dependent manner.
RT-PCR
Cell Line:
U-266 cells
Concentration:
2 μM
Incubation Time:
48 hours
Result:
Up-regulated the pro-apoptotic gene Bax and down-regulated the anti-apoptotic gene Bcl-2 and suppressed the expression of c-Myc and hTERT genes.
分子式
C20H16N2O6
分子量
380.35
CAS号
368449-04-1
运输条件
Room temperature in continental US; may vary elsewhere.