Opitor-0 是一种强效且选择性的线粒体动力相关蛋白视神经萎缩蛋白 1 (OPA1) 鸟苷三磷酸酶 (GTPase) 抑制剂，其 IC50 值为 3 μM。Opitor-0 可诱导线粒体碎片化和嵴重塑，破坏 OPA1 寡聚物的稳定性，并显著促进细胞色素 c 的释放，诱导凋亡 (apoptosis)。Opitor-0 与 Bcl-2 抑制剂 ABT-737 和 Venetoclax 具有协同抗肿瘤作用。Opitor-0 可用于对 Bcl-2 抑制剂耐药的恶性肿瘤研究，例如三阴性乳腺癌 (TNBC)。
| 生物活性 |
Opitor-0 is a potent and selective inhibitor of mitochondrial dynamin-related protein Optic Atrophy 1 (OPA1) guanosine triphosphatase (GTPase) with an IC50 of 3 μM. Opitor-0 can induce fragmentation of mitochondria and remodeling of cristae, disrupt the stability of OPA1 oligomers, and significantly enhance the release of cytochrome c and induce apoptosis. Opitor-0 has a synergistic antitumor effect with Bcl-2 inhibitors, such as ABT-737 and Venetoclax. Opitor-0 can be used for the research of malignant tumors that are resistant to Bcl-2 inhibitors, such as triple-negative breast cancer (TNBC). |
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| 分子式 |
C30H25N5O2S
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| 分子量 |
519.62
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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纯度： 98%
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