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Cell Cycle/DNA Damage——Haspin Kinase

Haspin is a protein kinase that regulates chromosome and spindle function during mitosis and meiosis. Haspin expression is detected in fetal liver, skin, kidney, small intestine and in all proliferating cells. Haspin phosphorylates H3 thr3 (H3T3ph) in human cell lines and depletion of Haspin by RNA interference reveals that Haspin is required for H3 thr3 phosphorylation in mitotic cells. Phosphorylation of H3T3ph by Haspin is necessary for chromosomal passenger complex (CPC) accumulation at centromeres. H3T3ph then positions the CPC at centromeres to regulate selected targets of Aurora B during mitosis.

Cell Cycle/DNA Damage——Haspin Kinase(3)

Cat. No. Product Name CAS No. Purity Chemical Structure
KM5651 CHR-6494

CHR-6494 是一种有效的 haspin 抑制剂,能够抑制组蛋白 H3T3 的磷酸化,IC50 值为 2 nM。

1333377-65-3 98%
KM11484 LDN-192960

LDN-192960 是 HaspinDYRK2 的双重抑制剂,IC50 值分别为 10 nM 和 48 nM。

184582-62-5 99%
KM11238 LDN-192960 hydrochloride

LDN-192960 hydrochloride 是 HaspinDYRK2 的双重抑制剂,IC50 值分别为 10 nM 和 48 nM。

2309172-48-1 ≥98%
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