Haspin is a protein kinase that regulates chromosome and spindle function during mitosis and meiosis. Haspin expression is detected in fetal liver, skin, kidney, small intestine and in all proliferating cells. Haspin phosphorylates H3 thr3 (H3T3ph) in human cell lines and depletion of Haspin by RNA interference reveals that Haspin is required for H3 thr3 phosphorylation in mitotic cells. Phosphorylation of H3T3ph by Haspin is necessary for chromosomal passenger complex (CPC) accumulation at centromeres. H3T3ph then positions the CPC at centromeres to regulate selected targets of Aurora B during mitosis.
| Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| KM5651 |
CHR-6494
CHR-6494 是一种有效的 haspin 抑制剂，能够抑制组蛋白 H3T3 的磷酸化，IC50 值为 2 nM。 |
1333377-65-3 | 98% |
|
| KM11484 |
LDN-192960
LDN-192960 是 Haspin 和 DYRK2 的双重抑制剂，IC50 值分别为 10 nM 和 48 nM。 |
184582-62-5 | 98% |
|
| KM11238 |
LDN-192960 hydrochloride
LDN-192960 hydrochloride 是 Haspin 和 DYRK2 的双重抑制剂，IC50 值分别为 10 nM 和 48 nM。 |
2309172-48-1 | ≥98% |
|
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