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Metabolic Enzyme/Protease——Carbonic Anhydrase

Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2 + H2O ⇋ HCO3- + H+. Eight genetically distinct carbonic anhydrase enzyme families (α-, β-, γ- δ-, ζ-, η-, θ- and ι- CAs) were described to date. Carbonic anhydrases are involved in numerous physiological and pathological processes. Many of them are important therapeutic targets with the potential to be inhibited to treat a range of disorders including oedema, glaucoma, obesity, cancer, epilepsy, and osteoporosis.

The carbonic anhydrase reaction is involved in many physiological and pathological processes, including respiration and transport of CO2 and bicarbonate between metabolizing tissues and lungs; pH and CO2 homeostasis; electrolyte secretion in various tissues and organs; biosynthetic reactions (such as gluconeogenesis, lipogenesis, and ureagenesis); bone resorption; calcification; and tumorigenicity. α-CAs are Zn2+ metalloproteins expressed in animals, vertebrates, prokaryotes, fungi, algae, protozoa, and plants. Sixteen mammalian α-CA isoforms are known to be involved in many diseases such as glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc.

Metabolic Enzyme/Protease——Carbonic Anhydrase(28)

Cat. No. Product Name CAS No. Purity Chemical Structure
KE9728 2,3-dihydro-1H-indene-5-sulfonamide 35203-93-1 ≥95%
KM12598 2-Aminobenzenesulfonamide

2-Aminobenzenesulfonamide 是碳酸酐酶 IX (carbonic anhydrase IX) 的抑制剂。

3306-62-5 99%
KE9730 4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide 654-62-6 ≥95%
KM14358 Acetazolamide

Acetazolamide 是一种碳酸酐酶 (carbonic anhydraseCA) IX 抑制剂,抑制 hCA IXIC50 为 30 nM。利尿剂。

59-66-5 99%
KM6541 Benzolamide

Benzolamide (CL11366) 是一种有效的碳酸酐酶 (CA) 抑制剂,抑制hCA IhCA IIEcoCAγVchCAγKi 值分别为15 nM,9 nM,94 nM 和 78 nM。Benzolamide 还抑制 CAS3Ki 值为 54 nM。Benzolamide 可用于青光眼和癫痫的研究。

3368-13-6 98%
KM19091 Benzthiazide

Benzthiazide 是一种长效的利尿剂和抗高血压剂。Benzthiazide 为碳酸酐酶 9 (carbonic anhydrase 9 (CA9)) 的抑制剂,对 CA9,CA2 和 CA1 的 Ki 值分别为 8.0,8.8 和 10 nM。Benzthiazide 能够抑制肿瘤细胞增殖。

91-33-8 99%
KM13534 Brinzolamide

Brinzolamide(AL 4862)是碳酸酐酶(carbonic anhydrase)II抑制剂,IC50为3.19 nM。

138890-62-7 99%
KE9729 Compound CDy9 952306-80-8 ≥95%
KM12157 Dichlorphenamide

Dichlorphenamide(Diclofenamide)是碳酸酐酶抑制剂。

120-97-8 98%
KM15117 Dimethylfraxetin

Dimethylfraxetin 是一种 Carbonic anhydrase 抑制剂,其 Ki 值为 0.0097 μM。

6035-49-0 99%
KM19066 Dorzolamide hydrochloride

Dorzolamide (L671152) hydrochloride 是有效的碳酸酐酶 carbonic anhydrase II 的抑制剂,其对红细胞CA-II 和CA-I 的 IC50 值分别为 0.18 nM 和 600 nM。

130693-82-2 99%
KM12866 Dorzolamide-d5

Dorzolamide-d5 (L671152-d5) 是 Dorzolamide 的氘代物。Dorzolamide (L671152) 是有效的碳酸酐酶 carbonic anhydrase II 的抑制剂,其对红细胞 CA-II 和 CA-I 的 IC50 值分别为 0.18 nM 和 600 nM。

1227097-70-2
KM7954 EMAC10101d

EMAC10101d 是有效的、选择性的 hCA II 抑制剂,其 Ki 值为 8.1 nM。

2561476-24-0 99%
KM18420 Ethoxzolamide

Ethoxzolamide 是 carbonic anhydrase 的抑制剂,其 Ki 值为 1 nM。

452-35-7 98%
KM18342 Fluorometholone acetate

Fluorometholone acetate 是一种合成的糖皮质激素皮质类固醇和皮质类固醇酯。Fluorometholone acetate 有效抑制碳酸酐酶 (CA) 对 hCA-IhCA-IIIC50 分别为 2.18 μM 和 17.5 μM。Fluorometholone acetate 具有抗炎作用,可用于外部眼部炎症的研究。

3801-06-7 ≥98%
KM18487 Halazone

Halazone 是一种非典型的抗菌磺酰胺衍生物,是碳酸酐酶 II (carbonic anhydrase II) 抑制剂,Kd 值为 1.45 µM。Halazone 可保护钠通道免于灭活。Halazone 被广泛用于饮用水消毒。

80-13-7 ≥90%
KM5154 Indisulam

Indisulam (E 7070) 是一种碳酸酐酶抑制剂,具有抗癌活性。Indisulam (E 7070) 是细胞周期 G1 期的靶向化合物。Indisulam (E 7070) 通过抑制 CDK2周期蛋白 E 的激活,引起 G1/S 转化被阻滞。Indisulam (E 7070) 通过募集 DCAF15 诱导 RBM39 降解来靶向剪接。

165668-41-7 99%
KM13642 Methazolamide

Methazolamide (L584601) 是一种磺胺衍生物,用作碳酸酐酶 (carbonic anhydrase) 抑制剂,对人 carbonic anhydrase II 的 Ki 为 14 nM。Methazolamide 是一种降低眼压的药物,可以降低青光眼和其他眼病引起的眼压升高。

554-57-4 99%
KM13884 Methyclothiazide

Methyclothiazide 是一种口服降压试剂 (antihypertensive) 和利尿剂 (diuretic agent)。Methyclothiazide 减少内源性血管收缩刺激 (如,去甲肾上腺素 ) 引起的血管反应。Methyclothiazide 拮抗体外的电压依赖性钙通道的 (VDCC) 活性。

135-07-9 99%
KE2974 Methyl 2,4-dihydroxybenzoate 2150-47-2 ≥95%
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