Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has amolecular mass of 96 kDa and it is a key regulator of cell cycle progression. Wee1 influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals. Wee1 inhibits Cdk1 by phosphorylating it on two different sites, Tyr15 and Thr14. Cdk1 is crucial for the cyclin-dependent passage of the various cell cycle checkpoints. At least three checkpoints exist for which the inhibition of Cdk1 by Wee1 is important: G2/M checkpoint, Cell size checkpoint, DNA damage checkpoint. Wee1 is shown to phosphorylate histone H2B at tyrosine 37 residue which regulates global expression of histones.
| Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| KM9631 |
Adavosertib
Adavosertib (AZD-1775; MK-1775) 是一种有效的 Wee1 抑制剂，IC50 值为 5.2 nM。 |
955365-80-7 | 98% |
|
| KM12851 |
PD 407824
PD 407824 是一个检查点激酶 Chk1 和 WEE1 抑制剂，IC50分别为 47 和 97 nM。PD 407824 是一种化学 BMP 敏化剂，可提高细胞对亚阈值量的 BMP4 的敏感性。 |
622864-54-4 | ≥98% |
|
| KM7170 |
PD0166285
PD0166285是 P-gp 的一个底物，是 WEE1 抑制剂，也可微弱抑制 Myt1，IC50 值分别为 24 和 72 nM。PD0166285 对 Chk1 的IC50 值为 3.433 μM。 |
185039-89-8 | 98% |
|
| KM6712 |
WEE1-IN-3
WEE1-IN-3 是一种有效的 Wee1 激酶抑制剂，其 IC50 <10 nM。WEE1-IN-3 具有抗癌活性。 |
2272976-28-8 | 98% |
|
| KM8902 |
ZN-c3
ZN-c3 是一种口服活性、高效和选择性 Wee1 抑制剂 (IC50=3.9 nM)。ZN-c3 可用于癌症研究。 |
2376146-48-2 |
|
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