Arenavirus genome includes two ambisense RNA segments that encode only four viral proteins: the envelope glycoprotein precursor, nucle-ocapsid protein, matrix zinc-binding (Z) protein and the large (L) RNA-dependent RNA polymerase (RdRp). The L protein is a multi-domain machinery with both transcription and replication activities. Similar to other segmented negative-sense RNA viruses (sNSVs), the replication of arenavirus genome is de novo initiated and involves a complementary RNA (cRNA) intermediate, whereas the transcription process presumably requires a host mRNA-derived primer captured by the viral polymerase through cap snatching.
Arenaviruses can cause severe haemorrhagic fever and neurological diseases in humans and other animals, exemplified by Lassa mammarenavirus, Machupo mammarenavirus and lymphocytic choriomeningitis virus, posing great threats to public health. These viruses encode a large multi-domain RNA-dependent RNA polymerase for transcription and replication of the viral genome. Viral polymerases are one of the leading antiviral therapeutic targets.
| Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| KM9785 |
(E)-LHF-535
(E)-LHF-535 是 LHF-535 的异构体. LHF-535 是一种抗病毒剂，对 Lassa，Machupo，Junin，VSVg 病毒的 EC50 分别为 <1 μM，<1 μM，<1 μM 和 1-10 μM，详细信息请参考专利文献 WO2012006552A1 中的化合物 1。 |
98% |
|
|
| KM12312 |
5,7-Dihydroxychromone
5,7-Dihydroxychromone 是一种 Cudrania tricuspidata 的提取物，可以激活 Nrf2/ARE 信号并对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。5,7-Dihydroxychromone 抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的 caspase-3，caspase-9 以及切割的 PARP 的表达。 |
31721-94-5 | 98% |
|
| KM13031 |
GP(33-41)
GP(33-41) 是一种由 9 个氨基酸残基组成的多肽，它是淋巴细胞性脉络丛脑膜炎病毒 GP1 抗原决定基中的最佳序列，能够上调 RMA-S (Db Kb) 细胞表面 H-2Db 分子，SC50 值为 344 nM。 |
161928-86-5 |
|
|
| KM2290 |
LHF-535
LHF-535 是一种抗病毒剂，对 Lassa，Machupo，Junin，VSVg 病毒的 EC50 分别为 <1 μM，<1 μM，<1 μM 和 1-10 μM，详细信息请参考专利文献 WO2012006552A1 中的化合物 1。 |
1450929-77-7 | 98% |
|
| KM5050 |
Retro-2 cycl
Retro-2 cycl (RN 1-001) 是一种逆行运输抑制剂。Retro-2 cycl (RN 1-001) 抑制 JCPyV 和 HPV16 伪病毒，IC50 分别为 54 μM 和 160 μM。 |
1429192-00-6 | 98% |
|
| KM2289 |
ST-193
ST-193是有效广谱的arenavirus抑制剂；抑制Guanarito, Junin, Lassa和Machupo病毒的IC50值分别为0.44, 0.62, 1.4 和3.1 nM。 |
489416-12-8 | 98% |
|
| KM6302 |
ST-193 hydrochloride
ST-193 hydrochloride是有效广谱的arenavirus抑制剂；抑制Guanarito, Junin, Lassa和Machupo病毒的IC50值分别为0.44, 0.62, 1.4 和3.1 nM。 |
2320274-72-2 | 98% |
|
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