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Cell Cycle/DNA Damage——Mps1

Monopolar spindle 1 (Mps1/TTK) is a serine/threonine kinase conserved from yeast to human. It has been shown to function as the key kinase that activates the spindle assembly checkpoint (SAC) to secure proper distribution of chromosomes to daughter cells.

MPS1, a dual specificity protein kinase, is also one of the main components of the SAC and ensures cells do not progress from metaphase to anaphase until the kinetochores are properly attached to the microtubules and under the appropriate tension at the metaphase plate. Cancer cells heavily rely on MPS1 to cope with aneuploidy resulting from aberrant numbers of chromosomes. The kinase has been found to be upregulated in a large number of tumor types. Mps1 is an attractive oncology target due to its high expression level in cancer cells as well as the correlation of its expression levels with histological grades of cancers.

Cell Cycle/DNA Damage——Mps1(11)

Cat. No.	Product Name	CAS No.	Purity
KM4704	AZ3146 AZ3146 是一种有效的选择性的 Mps1* 抑制剂，作用于 Mps1^Cat，IC₅₀ 为 35 nM。*	1124329-14-1	98%
KM3818	BAY1217389 BAY 1217389是具有高效性和选择性的(MPS1)激酶抑制剂，IC₅₀值小于10 nM。	1554458-53-5	98%
KM3402	BOS-172722 BOS-172722 是单极纺锤体 1 (MPS1)* 检查点的抑制剂，其对MPS1 (1 mM ATP) 和P-MPS1 的 IC₅₀ 值分别为 11 nM 和 63 nM。BOS-172722 可用于多种乳腺癌的研究。*	1578245-44-9	98%
KM8321	CCT251455 CCT251455是有效和选择性的有丝分裂激酶单极纺锤体1 (MPS1) 抑制剂，IC₅₀* 值为3 nM。*	1400284-80-1	98%
KM3815	Empesertib Empesertib (BAY 1161909) 是一种有效的 Mps1* 抑制剂，IC₅₀ 值 <1 nM。*	1443763-60-7	≥98%
KM3209	MPI-0479605 MPI-0479605 是一种有效的，选择性的，ATP 竞争性的 Mps1* 抑制剂，IC₅₀ 值为 1.8 nM。*	1246529-32-7	98%
KM6900	Mps1-IN-1 Mps1-IN-1 是一种有效的，选择性的，ATP 竞争性的 Mps1* 抑制剂，IC₅₀ 和 K_d 值分别为 367 nM 和 27 nM。*	1125593-20-5	98%
KM7526	Mps1-IN-2 Mps1-IN-2 是一种有效的，选择性的，ATP 竞争性的 Mps1/Plk1 双重抑制剂，对 Mps1 的 IC₅₀ 和 K_d 值分别为 145 nM 和 12 nM，对 Plk1 的 K_d 值为 61 nM。	1228817-38-6	98%
KM7680	Mps1-IN-3 Mps1-IN-3 是一种有效的，选择性的 MPS1* 抑制剂，IC₅₀ 值为 50 nM。*	1609584-72-6	98%
KM10329	NMS-P715 NMS-P715 是一种选择性的，ATP 竞争性的 MPS1* 抑制剂，IC₅₀ 值为 182 nM。*	1202055-32-0	98%
KM5437	TC-Mps1-12 TC-Mps1-12 是一种高效、选择性的 Mps1* 抑制剂，其 IC₅₀ 值为 6.4 nM。*	1206170-62-8	98%