TC-Mps1-12 - CAS:1206170-62-8

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TC-Mps1-12

目录号 : KM5437 CAS No. : 1206170-62-8 纯度 : 98%

Data Sheet 产品使用指南

TC-Mps1-12 是一种高效、选择性的 Mps1 抑制剂，其 IC₅₀ 值为 6.4 nM。

规格	价格	是否有货
1mg		In-stock
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC₅₀ of 6.4 nM.

体外研究

TC-Mps1-12 inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay.
TC-Mps1-12 (72 hours) inhibits the growth of cells in a dose-dependent manner and with an IC₅₀ values of 0.84 μM.

Cell Viability Assay

Cell Line:	549 cells
Concentration:
Incubation Time:	72 hours
Result:	Inhibited the growth of cells in a dose-dependent manner and with an IC₅₀ values of 0.84 μM.

体内研究

TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. At a dose of 100 mg/kg, TC-Mps1-12 exhibits 47% tumor growth inhibition without body weight loss.
TC-Mps1-12 shows good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg.

Animal Model:	A549 mouse xenograft model
Dosage:	25 mg/kg, 50 mg/kg, 100 mg/kg
Administration:	Oral administration; once daily; for 19 days
Result:	Inhibited the growth of A549 cells in a dose-dependent manner.

Animal Model:	A549 mouse xenograft model (pharmacokinetic )
Dosage:	25 mg/kg
Administration:	Oral administration
Result:	C_max = 3542 ng/mL, AUC = 6604 ng h/mL

分子式

C₁₇H₂₀N₆O

分子量

324.38

CAS号

1206170-62-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： 98%

Data Sheet

产品使用指南

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稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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