您当前的位置:
Cytoskeleton——Arp2/3 Complex

The Arp2/3 complex is originally identified in Acanthamoeba and consists of seven proteins (actin-related proteins; Arp2 and Arp3, and Arp2/3 complex subunits; ARPC1-5) that are conserved in all eukaryotes, with the exception of some algae, microsporidia and protists. The complex plays an essential role in a wide variety of cellular processes including lamellipodia-mediated cell migration, endocytosis and phagocytosis, by virtue of its ability to generate branched actin filament networks

.

Activation of Arp2/3 requires interaction with actin nucleation-promoting factors (NPFs). Regulation of Arp2/3 activity is achieved by endogenous inhibitory proteins through direct binding to Arp2/3 and competition with NPFs or by binding to Arp2/3-induced actin filaments and disassembly of branched actin networks. Arp2/3 inhibition has recently garnered more attention as it has been associated with attenuation of cancer progression, neurotoxic effects during drug abuse, and pathogen invasion of host cells.

Cytoskeleton——Arp2/3 Complex(8)

Cat. No. Product Name CAS No. Purity Chemical Structure
KM5047 Benproperine phosphate

Benproperine phosphate 是一种具有口服活性的,有效的肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。Benproperine phosphate 通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。Benproperine phosphate 有潜力用于止咳,并可以抑制癌细胞迁移和肿瘤转移。

19428-14-9 99%
KM11536 CK-636

CK-636是具有细胞渗透性的Arp2/3 复合体抑制剂,能抑制肌动蛋白的聚合,对人,裂殖酵母和牛的 IC50 值分别为4 μM,24 μM和32 μM。

442632-72-6 98%
KM12834 CK-666

CK-666 是一种细胞渗透性的与肌动蛋白相关的蛋白质 Arp2/3 复合物的抑制剂 (IC50=12 μM),它结合 Arp2/3 复合物,稳定复合物的非活性状态,阻止 Arp2 和 Arp3 亚单位移动进入激活的丝状构象。

442633-00-3 98%
KM12493 CK-869

CK-869 是肌动蛋白相关蛋白 2/3 复合体 (ARP2/3) 的抑制剂,其 IC50 值为 7 μM。

388592-44-7 99%
KM11433 Cytochalasin B

Cytochalasin B 是一种能透过细胞的真菌毒素,能够与肌动蛋白丝的有刺端结合,扰乱肌动蛋白聚合物的形成,对 F-actin 的 Kd 值为 1.4-2.2 nM。

14930-96-2 99%
KM20143 Cytochalasin D 22144-77-0 98%
KM19913 Jasplakinolide 102396-24-7
KM16530 Latrunculin A

Latrunculin A (LAT-A) 是从红海海绵 Latrunculia magnifica 中得到的一种毒素,能够与肌动蛋白 (actin) 单体结合,抑制肌动蛋白聚集,对 ATP-actin,ADP-Pi-actin,ADP-actin 和 G-actin 的 Kd 值分别为 0.1,0.4,4.7 μM 和 0.19 μM。

76343-93-6 ≥97%
在线客服
咨询热线
400-881-9290
关注微信公众号