CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation.
IC50&Target
HIV-1
体外研究
CK-666 (100 μM) significantly reduces the number of filopodia on the cell surface of treated trabecular meshwork (TM) cells as well as reduces the length of those filopodia that are present.
分子式
C18H17FN2O
分子量
296.34
CAS号
442633-00-3
运输条件
Room temperature in continental US; may vary elsewhere.