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Signal path
Autophagy | 自噬
Autophagy
FKBP
LRRK2
Mitophagy
ULK
Atg4
Beclin1
Immunology/Inflammation | 免疫及炎症
Arginase
Aryl Hydrocarbon Receptor
CCR
CD73
Complement System
COX
CXCR
Cyclic GMP-AMP Synthase
FKBP
FLAP
Galectin
Histamine Receptor
IFNAR
Interleukin Related
IRAK
MyD88
NO Synthase
NOD-like Receptor (NLR)
PD-1/PD-L1
PGE synthase
Pyroptosis
Reactive Oxygen Species
Salt-inducible Kinase (SIK)
SphK
STING
Thrombopoietin Receptor
Toll-like Receptor (TLR)
FAP
AIM2
AP-1
ALCAM/CD166
CD2
CD3
CD6
CD19
CD20
CD22
CD28
CD38
CX3CR1
CTLA-4
DOCK
Glycoprotein VI
Glucocorticoid Receptor
Mucin
Mesothelin
Macrophage migration inhibitory factor (MIF)
Nuclear Factor of activated T Cells (NFAT)
PSMA
SOD
Tim3
Immunology/Inflammation related
CD74
P-selectin
Nectin-4
NF-κB Metabolic Enzyme/Protease
VAP-1
LAG-3
Kallikrein
NTPDase
Transmembrane Glycoprotein
CD47
Fc Receptor (FcR)
CD276/B7-H3
C-type Lectin-like Receptors (CTLRs)
Human leukocyte immunoglobulin (Ig)-like receptors (LILR)
Neuronal Signaling | 神经信号通路
5-HT Receptor
AChE
Adenosine Kinase
Adrenergic Receptor
Amyloid-β
Beta-secretase
Calcium Channel
CaMK
Cannabinoid Receptor
Dopamine Transporter
CGRP Receptor
Cholecystokinin Receptor
COMT
Dopamine Receptor
FAAH
GABA Receptor
GlyT
GPR119
GPR139
GPR55
Histamine Receptor
iGluR
Imidazoline Receptor
mAChR
MCHR1 (GPR24)
Melanocortin Receptor
Melatonin Receptor
mGluR
Monoamine Oxidase
nAChR
Neurokinin Receptor
Neuropeptide Y Receptor
Neurotensin Receptor
Notch
Opioid Receptor
Orexin Receptor (OX Receptor)
Serotonin Transporter
Sigma Receptor
Somatostatin Receptor
Trk Receptor
TRP Channel
γ-secretase
Cholinesterase (ChE)
AAK1
α-synuclein
Glucosylceramide Synthase (GCS)
Huntingtin
Tau Protein
Transthyretin (TTR)
AChR
Prion Protein
Protein Tyrosine Kinase/RTK | 蛋白酪氨酸激酶
Ack1
ALK
Bcr-Abl
BMX Kinase
Btk
c-Fms
c-Kit
c-Met/HGFR
Discoidin Domain Receptor
Itk
DYRK
EGFR
Ephrin Receptor
FAK
FGFR
FLT3
IGF-1R
Insulin Receptor
PDGFR
PKA
Pyk2
RET
ROS
Src
Syk
TAM Receptor
Trk Receptor
VEGFR
JAK
SHP2
Anaplastic lymphoma kinase (ALK)
ROS Kinase
Tie
TGF-beta/Smad | TGF-beta/Smad 信号通路
PKC
ROCK
TGF-beta/Smad
TGF-β Receptor
Dan family
MAPK/ERK Pathway | MAPK/ERK 信号通路
ERK
JNK
KLF
MAP3K
MAP4K
MAPKAPK2 (MK2)
MEK
Mixed Lineage Kinase
MNK
Raf
p38 MAPK
Ribosomal S6 Kinase (RSK)
Ras
JAK/STAT Signaling | JAK/STAT 信号通路
EGFR
JAK
Pim
STAT
GPCR/G Protein | G 蛋白偶联受体/G 蛋白
5-HT Receptor
Adenosine Receptor
Adenylate Cyclase
Adiponectin Receptor
Adrenergic Receptor
Angiotensin Receptor
Bombesin Receptor
Bradykinin Receptor
Cannabinoid Receptor
CaSR
CCR
CGRP Receptor
Cholecystokinin Receptor
CRFR
CXCR
Dopamine Receptor
EBI2/GPR183
Endothelin Receptor
GHSR
Glucagon Receptor
Glucocorticoid Receptor
GnRH Receptor
GPCR19
GPR109A
GPR119
GPR120
GPR139
GPR40
GPR55
GPR84
Guanylate Cyclase
Histamine Receptor
Imidazoline Receptor
Leukotriene Receptor
LPL Receptor
mAChR
MCHR1 (GPR24)
Melanocortin Receptor
Melatonin Receptor
mGluR
Motilin Receptor
Neurokinin Receptor
Neuropeptide Y Receptor
Neurotensin Receptor
Opioid Receptor
Orexin Receptor (OX Receptor)
Oxytocin Receptor
P2Y Receptor
Prostaglandin Receptor
Protease-Activated Receptor (PAR)
Ras
RGS Protein
Sigma Receptor
Somatostatin Receptor
TSH Receptor
Urotensin Receptor
Vasopressin Receptor
Apelin Receptor (APJ)
Amylin Receptor
GCGR
GLP Receptor
PTHR
Secretin Receptor
Arrestin
G Protein-coupled Receptor Kinase (GRK)
Formyl Peptide Receptor (FPR)
Free Fatty Acid Receptor
GPR4
GPR6
GPR68
GPR88
GPR35
GPR52
GPR171
Kisspeptin Receptor
Succinate Receptor 1
G protein-coupled Bile Acid Receptor 1
Hydroxycarboxylic Acid Receptor (HCAR)
Hydroxycarboxylic Acid Receptor (HCAR)
Platelet-activating Factor Receptor (PAFR)
Trace Amine-associated Receptor (TAAR)
Mas-related G-protein-coupled Receptor (MRGPR)
GPR
Orphan GPCR
Natriuretic Peptide Receptor (NPR)
Cell Cycle/DNA Damage | 细胞周期/DNA 损伤
Antifolate
APC
ATM/ATR
Aurora Kinase
Casein Kinase
CDK
Checkpoint Kinase (Chk)
CRISPR/Cas9
Deubiquitinase
DNA Alkylator/Crosslinker
DNA-PK
DNA/RNA Synthesis
Eukaryotic Initiation Factor (eIF)
G-quadruplex
Haspin Kinase
HDAC
HSP
IRE1
Kinesin
LIM Kinase (LIMK)
Microtubule/Tubulin
Mps1
Nucleoside Antimetabolite/Analog
p97
PAK
PARP
PERK
Polo-like Kinase (PLK)
PPAR
RAD51
ROCK
Sirtuin
SRPK
Telomerase
TOPK
Topoisomerase
Wee1
Cyclin G-associated Kinase (GAK)
Early 2 Factor (E2F)
DNA Stain
ATF6
PDI
NEKs
Apoptosis | 凋亡
Apoptosis
Bcl-2 Family
c-Myc
Caspase
DAPK
Ferroptosis
FKBP
IAP
MDM-2/p53
PKD
Pyroptosis
RIP kinase
Survivin
Thymidylate Synthase
TNF Receptor
Necroptosis
Transferrin Receptor
ADC Related | 抗体偶联药物相关
ADC Cytotoxin
ADC Linkers
Antibody-Drug Conjugates (ADCs)
Drug-Linker Conjugates for ADC
PROTAC-Linker Conjugates for PAC
ADC Antibody
Antibody-Oligonucleotide Conjugates (AOCs)
NF-κB | NF-κB 信号通路
IKK
Keap1-Nrf2
MALT1
NF-κB
Reactive Oxygen Species
RANKL/RANK
PI3K/Akt/mTOR | PI3K/Akt/mTOR 信号通路
Akt
AMPK
ATM/ATR
DNA-PK
GSK-3
MELK
mTOR
PDK-1
PI3K
PI4K
PIKfyve
PTEN
PIN1
Stem Cell/Wnt | 干细胞及 Wnt 通路
Casein Kinase
ERK
Gli
GSK-3
Hedgehog
Hippo (MST)
JAK
Notch
Oct3/4
β-catenin
PKA
Porcupine
ROCK
sFRP-1
Smo
STAT
TGF-beta/Smad
Wnt
YAP
γ-secretase
Annexin A
PROTAC | 蛋白降解靶向嵌合体
ATTECs
AUTACs
E3 Ligase Ligand-Linker Conjugates
Ligands for E3 Ligase
Ligands for Target Protein for PROTAC
LYTACs
Molecular Glues
PROTACs Linkers
PROTAC-Linker Conjugates for PAC
PROTACs
SNIPERs
Target Protein Ligand-Linker Conjugates
Membrane Transporter/Ion Channel | 跨膜转运
ATP Synthase
BCRP
Calcium Channel
CFTR
Chloride Channel
CRAC Channel
CRM1
EAAT
GABA Receptor
HCN Channel
GLUT
GlyT
iGluR
Monoamine Transporter
Monocarboxylate Transporter
Na+/Ca2+ Exchanger
Na+/HCO3- Cotransporter
Na+/K+ ATPase
nAChR
NKCC
P-glycoprotein
P2X Receptor
Potassium Channel
Proton Pump
SGLT
Sodium Channel
TRP Channel
URAT1
VDAC
Aquaporin
Apical Sodium-Dependent Bile Acid Transporter
Calmodulin
Na+/H+ Exchanger (NHE)
Urea Transporter
Piezo Channel
SLC39 (Zinc Transporter)
Epigenetics | 表观遗传学
AMPK
Aurora Kinase
DNA Methyltransferase
Epigenetic Reader Domain
HDAC
Histone Acetyltransferase
Histone Demethylase
Histone Methyltransferase
JAK
MicroRNA
PARP
PKC
Protein Arginine Deiminase
Sirtuin
Small Interfering RNA (siRNA)
Cytoskeleton | 细胞骨架
Arp2/3 Complex
Dynamin
Gap Junction Protein
Integrin
Kinesin
Microtubule/Tubulin
Mps1
Myosin
PAK
ROCK
Annexin A
Connexin
Dystrophin
Cadherin
Claudin
Natural Lipids | 天然脂质
Natural Lipids
Anti-infection | 抗感染
Antibiotic
Arenavirus
Bacterial
CMV
Enterovirus
Filovirus
Fungal
HBV
HCV
HCV Protease
HIV
HIV Protease
HSV
Influenza Virus
Parasite
Reverse Transcriptase
RSV
SARS-CoV
Virus Protease
Orthopoxvirus
EBV
Antiviral
RABV
HPV
Dengue Virus
Metabolic Enzyme/Protease | 代谢酶/蛋白酶
Aldose Reductase
Carbonic Anhydrase
Enolase
Glucokinase
Glucosidase
Glutathione Peroxidase
Hexokinase
HIF/HIF Prolyl-Hydroxylase
NADPH Oxidase
Lactate Dehydrogenase
Mineralocorticoid Receptor
Mitochondrial Metabolism
NAMPT
PGC-1α
Phosphatase
Pyruvate Kinase
Reactive Oxygen Species
SGK
15-PGDH
5 alpha Reductase
Acetyl-CoA Carboxylase
Acyltransferase
Aldehyde Dehydrogenase (ALDH)
ATGL
ATP Citrate Lyase
CETP
Cytochrome P450
Epoxide Hydrolase
FAAH
FABP
Fatty Acid Synthase (FASN)
FXR
HMG-CoA Reductase (HMGCR)
Isocitrate Dehydrogenase (IDH)
Lipoxygenase
LXR
MAGL
Mitochondrial Metabolism
NADPH Oxidase
PDHK
PGC-1α
Phosphatase
Phospholipase
RAR/RXR
Reactive Oxygen Species
ROR
Stearoyl-CoA Desaturase (SCD)
Adenosine Deaminase
Adenosine Kinase
Aminopeptidase
Angiotensin-converting Enzyme (ACE)
Arginase
Carboxypeptidase
Cathepsin
COMT
Dipeptidyl Peptidase
Dopamine β-hydroxylase
E1/E2/E3 Enzyme
Elastase
Factor Xa
Farnesyl Transferase
Glutaminase
GSNOR
Gutathione S-transferase
HCV Protease
HIV Protease
HSP
Indoleamine 2,3-Dioxygenase (IDO)
Isocitrate Dehydrogenase (IDH)
MALT1
MMP
NADPH Oxidase
NEDD8-activating Enzyme
Neprilysin
PAI-1
Phosphatase
Procollagen C Proteinase
Proteasome
Reactive Oxygen Species
Renin
Ser/Thr Protease
Thrombin
Tryptophan Hydroxylase
Tyrosinase
Xanthine Oxidase
Aminoacyl-tRNA Synthetase
Dihydroorotate Dehydrogenase
HIV Integrase
Phosphodiesterase (PDE)
Drug Metabolite
Endogenous Metabolite
Liposome
Amylases
Ceramidase
Cryptochrome
DGK
Dihydrofolate reductase (DHFR)
Furin
FBPase
Factor VIII
Fat Mass and Obesity-associated Protein (FTO)
Methionine Adenosyltransferase (MAT)
Methylenetetrahydrofolate Dehydrogenase (MTHFD)
Microsomal Triglyceride Transfer Protein (MTP)
PEPCK
Prolyl Endopeptidase (PREP)
Phosphoglycerate Dehydrogenase (PHGDH)
Glyoxalase (GLO)
TrxR
Transketolase
17β-HSD
11β-HSD
LDLR
HPPD
Acetolactate Synthase (ALS)
Dehydrogenase
UGT
REV-ERB
Dihydroorotate Dehydrogenase
Serpin
Factor XI
PCSK9
Herbicide
Ser/Thr Kinase
Glutathione S-transferase
ADAMTS
PCSK9
Glycosidase
GHR
ANGPTL
DAGL
Hepcidin
Steroid Sulfatase
Apolipoprotein
Vitamin D Related | 维生素 D 相关
VD/VDR
RAR/RXR
Glucocorticoid Receptor
Mineralocorticoid Receptor
REV-ERB
Estrogen Receptor/ERR
Androgen Receptor
Thyroid Hormone Receptor
ROR
PPAR
LXR
Progesterone Receptor
Thyroid Hormone Receptor
Pyroptosis | 细胞焦亡
Inhibitory Antibodies | 抗体抑制剂
Others | 其他
Bioactive Peptides
Androgen Receptor
Aromatase
Estrogen Receptor/ERR
Progesterone Receptor
Thyroid Hormone Receptor
Others
Cellular Metabolism
Receptors
Biochemicals
Isotope-Labeled Compounds
Fluorescent Dye
Amino Acid Derivatives
Biochemical Assay Reagents
Oligonucleotides
Antioxidant
Protease Inhibitor Cocktail
Amino Acid Derivatives
Drug Intermediate
Drug Derivative
Drug Isomer
Insecticide
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Metabolic Enzyme/Protease | 代谢酶/蛋白酶
PCSK9
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