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Cell Cycle/DNA Damage——Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Cell Cycle/DNA Damage——Nucleoside Antimetabolite/Analog(109)

Cat. No. Product Name CAS No. Purity Chemical Structure
KE7370 1-Methylcytosine 1122-47-0 ≥95%
KM4022 1-Methylinosine

1-Methylinosine 是位于真核生物 tRNA 的反密码子在 tRNA 3' 端位点 37 处的一种修饰核苷酸。

2140-73-0 99%
KG13022 2′-C-β-Methylguanosine 374750-30-8 >90%
KM20090 2′-Deoxy-2′-fluoroadenosine 64183-27-3 ≥97%
KM3906 2'-Deoxypseudoisocytidine

2'-Deoxypseudoisocytidine 是一个核苷类似物。

65358-18-1
KM6374 2’-O,4’-C-Methyleneuridine

2’-O,4’-C-Methyleneuridine (Compound 15a) 是一种双环核苷。

200435-92-3 99%
KM7957 2'-O-Me-C(Bz) Phosphoramidite

2'-O-Me-C(Bz) Phosphoramidite 是一种修饰过的亚磷酰胺单体,可用于寡核苷酸的合成。

110764-78-8
KM10975 2'-OMe-A(Bz) Phosphoramidite

2'-OMe-A(Bz) Phosphoramidite 是一种修饰过的亚磷酰胺单体,可用于寡核苷酸的合成。

110782-31-5 98%
KM11136 2'-OMe-G(ibu) Phosphoramidite

2'-OMe-G(ibu) Phosphoramidite 是一种修饰过的亚磷酰胺单体,可用于寡核苷酸的合成。

150780-67-9
KM6911 3'-Azido-3'-deoxy-5-fluorocytidine

3'-Azido-3'-deoxy-5-fluorocytidine (Compound 12) 是一种胞苷衍生物。

2095417-18-6 99%
KM6912 3'-Azido-3'-deoxy-beta-L-uridine

3'-Azido-3'-deoxy-beta-L-uridine (Compound 25) 是一种核苷衍生物。

2095417-28-8 99%
KM11373 3'-Deoxyuridine-5'-triphosphate

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) 是一种核苷酸类似物,可抑制 DNA 依赖性 RNA 聚合酶 I 和 II (RNA polymerases III),强烈并竞争性地抑制 UTP 掺入到 RNA 中,Ki 值为 2.0 μM。

69199-40-2
KM7726 3'-Deoxyuridine-5'-triphosphate trisodium

3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) 是一种核苷酸类似物,可抑制 DNA 依赖性 RNA 聚合酶 I 和 II (RNA polymerases III),强烈并竞争性地抑制 UTP 掺入到 RNA 中,Ki 值为 2.0 μM。

99%
KM8533 3-Methylcytidine

3-Methylcytidine 是一种尿核苷,可用作四种不同类型癌症 (肺癌,胃癌,结肠癌和乳腺癌) 的生物标志物。

2140-64-9 98%
KM6733 5'-O-DMT-2'-O-TBDMS-Ac-rC

5'-O-DMT-2'-O-TBDMS-Ac-rC 是一种修饰的核苷,可以用于合成 DNA 或 RNA。

121058-85-3
KM13607 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine

5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine 是一种腺苷衍生物,可作为寡核苷酸合成的中间体 (intermediate)。

81265-93-2 99%
KM13959 5'-O-DMT-2'-TBDMS-Uridine

5'-O-DMT-2'-TBDMS-Uridine 是一种脱氧核糖核苷,可用于寡核苷酸的合成。

81246-80-2 99%
KM8165 5'-O-DMT-3'-O-TBDMS-Ac-rC

5'-O-DMT-3'-O-TBDMS-Ac-rC 是一种修饰的核苷,可以用于合成 DNA 或 RNA。

123956-65-0 99%
KM6732 5'-O-DMT-Bz-rC

5'-O-DMT-Bz-Rc 是一种修饰的核苷,可以用于合成 DNA 或 RNA。

81246-76-6
KM8754 5'-O-DMT-N4-Ac-2'-F-dC

5'-O-DMT-3'-O-TBDMS-Ac-rC是一种修饰的核苷,可以用于合成 DNA 或 RNA。

159414-98-9
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