ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer.
体外研究
ZN-c3 IC50 is 103 nM in H23 cells.
体内研究
ZN-c3 (80 mg/kg; p.o.; 28 days) can effectively shrank tumors at 80 mg/kg as a single agent.
ZN-c3 shows excellent exposures and bioavailability in the dog PK study.
分子式
C29H34N8O2
分子量
526.63
CAS号
2376146-48-2
运输条件
Room temperature in continental US; may vary elsewhere.