Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures.
体外研究
Benzolamide inhibits hCA I, hCA II, EcoCAγ and VchCAγ, with Kis of 15 nM, 9 nM, 94 nM and 78 nM, respectively.
Benzolamide shows selectivity for CAS3 (Ki=54 nM) over CAS1 (Ki=2115 nM) and CAS2 (Ki=410 nM).
体内研究
Benzolamide (90 µmol/kg; i.p.) decreases brain pH and suppresses electrographic post-asphyxia seizures in rats.
Animal Model:
Male and female Wistar Han rats (11-day-old)
Dosage:
90 µmol/kg
Administration:
A single i.p.
Result:
Induced a fast brain acidosis of a comparable magnitude.
Suppressed electrographic seizures after asphyxia by slowing down the recovery of brain pH.
分子式
C8H8N4O4S3
分子量
320.37
CAS号
3368-13-6
中文名称
苯唑拉胺
运输条件
Room temperature in continental US; may vary elsewhere.