| 生物活性 |
Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM). telomerase-IN-1 activates hTERT expression through the endoplasmic reticulum stress (ERS) of the ER overreaction (EOR), which then induces ERS, leading to apoptosis. telomerase-IN-1 leads to inhibition of cell proliferation through the expression of downstream signaling molecules including Telomease-IN-1 has high inhibitory activity against telomerase, high anti-proliferative capacity against SMMC-7721 cells, and no significant toxic effect on human normal hepatocytes. telomerase-IN-1 in xenograft tumor model exhibited antitumor activity.
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 分子式 |
C21H23FN2O4
|
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| 分子量 |
386.42
|
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| CAS号 |
666859-49-0
|
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| 中文名称 |
Methanone, (4-fluorophenyl)[1-[2-methoxy-2-(4-nitrophenyl)ethyl]-4-piperidinyl]-
|
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
|
纯度： ≥95%
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