Cisplatin - CAS:15663-27-1

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Cisplatin (Synonyms:顺铂; cis-Platinum; CDDP; cis-Diaminodichloroplatinum)

目录号 : KM16283 CAS No. : 15663-27-1 纯度 : 98%

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Cisplatin (CDDP) 是一种抗肿瘤的化疗剂，它与 DNA 交联引起癌细胞中 DNA 损伤。Cisplatin 可激活铁死亡 (ferroptosis) 并诱导自噬 (autophagy)。

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100mg		In-stock
500mg		In-stock
1g		In-stock
5g	询价	In-stock
10g	询价	In-stock

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生物活性

Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy.

体外研究

Cisplatin (CDDP) causes apoptosis of HeLa cells in a dose-dependent manner, with a concentration of 30 μM Cisplatin resulting in death of greater than 90% of the cell population by 24 h of treatment. The kinetics of Cisplatin-induced apoptosis are examined using a 30 μM concentration. Cisplatin Activates the MEK/ERK Signaling Pathway, 20 and 30 μM Cisplatin, both of which results in significant apoptosis, leads to strong activation of ERK.
Cisplatin (50 μM) produces time-dependent apoptosis in renal proximal tubular cell (RPTCs), causing cell shrinkage, a 50-fold increase in caspase 3 activity, a 4-fold increase in phosphatidylserine externalization, and 5- and 15-fold increases in chromatin condensation and DNA hypoploidy, respectively.

体内研究

In melanoma-bearing mice, Cisplatin (CDDP; 4 mg/kg B.W.) reduces the size and weight of the solid tumors, and HemoHIM supplementation with Cisplatin enhances the decrease of both the tumor size and weight.
Cisplatin administration results in significant increases in the kidney weight as a percentage of the total body weight, urine volume, serum creatinine, and blood urea nitrogen by about 132, 315, 797, and 556% in comparison with the control rats, respectively.

分子式

Cl₂H₄N₂Pt

分子量

300.05

CAS号

15663-27-1

中文名称

顺铂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMF : 5 mg/mL (16.66 mM; Need ultrasonic; DMSO can inactivate Cisplatin's activity)

H₂O : 1 mg/mL (3.33 mM; Need ultrasonic; DMSO can inactivate Cisplatin's activity)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3328 mL	16.6639 mL	33.3278 mL
5 mM	0.6666 mL	3.3328 mL	6.6656 mL
10 mM	0.3333 mL	1.6664 mL	3.3328 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 0.5% CMC-Na/saline water
Solubility: 20 mg/mL (66.66 mM); Suspended solution; Need ultrasonic
2.

请依序添加每种溶剂： 50% PEG300 50% saline
Solubility: 10 mg/mL (33.33 mM); Suspended solution; Need ultrasonic

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科研文献

纯度： 98%

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