NCOA4 - 9a is a novel and highly selective ferroptosis inhibitor, and the first small molecule inhibitor targeting the interaction between NCOA4-FTH1 proteins. NCOA4-9a directly binds to NCOA4 protein, effectively disrupting the protein-protein interaction between NCOA4 and FTH1, hindering the degradation of ferritin, and reducing the level of free ferrous ions (Fe ² ⁺) in cells. Therefore, it can inhibit Erastin induced ferroptosis,EC50 =0.29 μM.
分子式
C27H28FN5
分子量
441.54
CAS号
2650557-72-3
中文名称
NCOA4 - 9a
运输条件
Room temperature in continental US; may vary elsewhere.