Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
IC50&Target
DNA Alkylator
体外研究
Carmustine is an antitumor chemotherapeutic agent. Carmustine (8, 80, and 800 µM) decreases N-acetyltransferase (NAT) activities for 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) in rat glial tumor cytosol and intact cells. In rat glial tumor cells, the DNA-AF adduct increases, and carmustine decreases the formation of DNA-AF adduct.
体内研究
Carmustine (BCNU; 25 mg/kg, i.p.) causes higher levels of the rhe ratio of liver weight to body weight and plasma conjugated bilirubin, and lower biliary flow, oxidised glutation levels (GSSG) and reduced glutation (GSH)/GSSG values compared with control rats.
分子式
C5H9Cl2N3O2
分子量
214.05
CAS号
154-93-8
中文名称
卡莫司汀;卡氮芥;亚硝脲氮芥;氯乙亚硝脲;卡莫斯汀;卡莫司丁
运输条件
Room temperature in continental US; may vary elsewhere.