Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
IC50&Target
MMP2
MMP9
体内研究
Morroniside reduces the expression of MMP2 and MMP9 in an I/R injury model. Treatment with Morroniside significantly reduces I/R‑associated neuron apoptosis in a dose dependent manner. The results demonstrate that active caspase‑3 and Bax are significantly upregulated in the model group compared with the control group, while Bcl‑2 is significantly downregulated. The expression of active caspase‑3 and Bax is significantly downregulated by Morroniside treatment in a dose‑dependent manner, while the expression of Bcl‑2 is significantly upregulated. Morroniside has an ameliorative effect on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice.
分子式
C17H26O11
分子量
406.38
CAS号
25406-64-8
中文名称
莫诺苷
运输条件
Room temperature in continental US; may vary elsewhere.