Vildagliptin - CAS:274901-16-5

您当前的位置：

Vildagliptin (Synonyms:维格列汀; LAF237; NVP-LAF 237)

目录号 : KM10868 CAS No. : 274901-16-5 纯度 : 98%

Data Sheet 产品使用指南

Vildagliptin (LAF237) 是一种有效且稳定的选择性二肽基肽酶IV (DPP-IV) 抑制剂，在人 Caco-2 细胞中抑制 DPP-IV 的 IC₅₀ 为 3.5 nM。Vildagliptin 具有出色的口服生物利用度和有效的降血糖活性。

规格	价格	是否有货
10mg		In-stock
50mg		In-stock
100mg		In-stock
500mg		In-stock
1g	询价	In-stock
5g	询价	In-stock

查看所有商品（1）

加入购物车大包装询价

Other Forms of Rapamycin:

Ginkgolide C In-stock
RP 70676 In-stock
Heptasaccharide Glc4Xyl3 In-stock
Fructo-oligosaccharide DP12/GF11 In-stock
6-Hydroxypyridin-2(1H)-one hydrochloride In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.

体外研究

Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation.

体内研究

Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice.
Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats.

Animal Model:	Male db/db mice (BKS) and wildtype mice
Dosage:	35 mg/kg
Administration:	Oral gavage; once daily; for 6 weeks
Result:	Increased plasma active GLP-1 levels (22.63±1.19 vs. 11.69±0.44).

Animal Model:	Obese male Zucker rats
Dosage:	10 µmol/kg (Pharmacokinetic Analysis)
Administration:	Orally
Result:	Significantly decreased glucose excursions and stimulate insulin secretion.

分子式

C₁₇H₂₅N₃O₂

分子量

303.40

CAS号

274901-16-5

中文名称

维达列汀；维格列汀

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 50 mg/mL (164.80 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.2960 mL	16.4799 mL	32.9598 mL
5 mM	0.6592 mL	3.2960 mL	6.5920 mL
10 mM	0.3296 mL	1.6480 mL	3.2960 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

1.

Vildagliptin is added to drinking water at a concentration of 150 mg/L for rats or 300 mg/L for mice.

临床试验

科研文献

纯度： 98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 2 篇科研文献

The molarity calculator equation

The dilution calculator equation