17(S)-HETE - CAS:183509-25-3

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17(S)-HETE

目录号 : KCM12145 CAS No. : 183509-25-3 纯度 : ≥98%

Data Sheet 产品使用指南

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney.17(S)-HETE inhibits proximal tubule ATPase activity by as much as 70% at a concentration of 2 µM.

规格	价格	是否有货	数量
25μg		In-stock
50μg		In-stock
100μg		In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

Sodium chloride, for cell culture In-stock
Ouabain In-stock
17(S)-HETE In-stock
(±)17-HETE In-stock
(±)16-HETE In-stock

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生物活性

17(S)-HETE is arachidonic acid metabolite through cytochrome P-450 pathways. 17(S)-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy.

体外研究

17(S)-HETE (5-20 μM) promotes the development of human cardiac hypertrophy by enhancing the activity and protein levels of CY1B1.

Real Time qPCR

Cell Line:	AC16
Concentration:	5-20 µM
Incubation Time:	24 hours
Result:	Increased β/α-MHC ratio, mRNA levels of β-MHC, ANP and CYP1B1, cell surface area by 124%, 250%, 120%, 210% and 117%, respectively.

Western Blot Analysis

Cell Line:	AC16
Concentration:	20 µM
Incubation Time:	24 hours
Result:	Increased levels of CYP1B1.

体内研究

17(S)-HETE (1-20 μg, arterial injection) inhibits proximal tubular ATPase activity in New Zealand white rabbits.

Animal Model:

New Zealand White rabbit

Dosage:

1-20 μg

Administration:

injection into artery

Result:

Inhibited more than 70% ATPase activity at the concentration of 2 μM.

分子式

C₂₀H₃₂O₃

分子量

320.47

CAS号

183509-25-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

暂无相关参考文献

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

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计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation

动物实验计算换算器