(±)16-HETE - CAS:128914-46-5

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(±)16-HETE

目录号 : KCM10935 CAS No. : 128914-46-5 纯度 : ≥98%

Data Sheet 产品使用指南

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 µM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.

规格	价格	是否有货	数量
25μg		In-stock
50μg		In-stock
100μg		In-stock

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生物活性

16-HETE is arachidonic acid metabolite through subterminal hydroxylation by cytochrome P-450. 16-HETE exhibits vasodilatory and PMN inhibitory effects and serves as biomarker for early stages of non-alcoholic fatty liver disease[1].

体外研究

16-HETE (0.01-1 μM) specifically inhibits the aggregation and adhesion of polymorphonuclear leukocytes, but has no significant effect on platelet function and blood pressure [1].

体内研究

16-HETE (1-20 μg, arterial injection) participates stereospecifically (S-enantiomer) in vasodilation, renal perfusion regulation, and tubular transport mechanisms in New Zealand white rabbits [2].
16-HETE (1 μg/kg/min) can inhibit the increase of intracranial pressure (ICP) in the thromboembolic stroke model of New Zealand white rabbits [1].

Animal Model:

New Zealand White rabbit

Dosage:

1-20 μg

Administration:

injection into artery

Result:

16S inhibited 60% ATPase activity at the concentration of 2 μM, while 16R enantiomer remained inactive.

Animal Model:	New Zealand White rabbit
Dosage:	1 μg/kg/min
Administration:	6 hours constant infusion from Hours 1 to 2 after autologous clot embolization
Result:	Reduced infarction area and less increased ICP.

分子式

C₂₀H₃₂O₃

分子量

320.5

CAS号

128914-46-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

[1]. Bednar MM, et al., 16(R)-hydroxyeicosatetraenoic acid, a novel cytochrome P450 product of arachidonic acid, suppresses activation of human polymorphonuclear leukocyte and reduces intracranial pressure in a rabbit model of thromboembolic stroke. Neurosurgery. 2000 Dec;47(6):1410-8; discussion 1418-9.

[2]. Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271(4 Pt 2):R863-9.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

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浓度

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动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

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第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

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计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器