L-Methionine-(S,R)-Sulfoximine - CAS:15985-39-4

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L-Methionine-(S,R)-Sulfoximine (Synonyms:L-蛋氨酸磺酸盐;MSX; MSO)

目录号 : KCM11760 CAS No. : 15985-39-4 纯度 : ≥95%

Data Sheet SDS 产品使用指南

L-Methionine-(S,R)-sulfoximine is an inhibitor of glutamine synthetase and a sulfoximine derivative of L-methionine. It inhibits pea glutamine synthetase by 31 to 64% when used at concentrations ranging from 5 to 25 µM following preincubation with L-glutamine, an effect that is absent without L-glutamine preincubation. It also inhibits glutamine synthetase in isolated chick embryo retinas.

规格	价格	是否有货	数量
10 mM * 1 mL in Water		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock

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生物活性

L-Methionine-(S,R)-Sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-(S,R)-Sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating Gln deficit-dependent depression. L-Methionine-(S,R)-Sulfoximine tremendously increases the rate of release of fixed nitrogen in cyanobacteria. L-Methionine-(S,R)-Sulfoximine is a promising candidate for research in biofertilizers and convulsive seizures (CS).

体内研究

L-Methionine - (S, R) - Sulfoximine (75 mg/kg, intraperitoneal injection, 210 minutes) had no effect on hippocampal glutamine synthetase (GS) activity and GS protein expression in rats during the first 150 minutes, but significantly reduced GS activity during the last 165-210 minutes. In addition, L-Methionine - (S, R) - Sulfoximine also reduced the intensity of seizures (CS) and epileptic seizures induced by administration of pilo in rats.
L-Methionine - (S, R) - Sulfoximine (75 mg/kg, intraperitoneal injection) reduced K+- induced depolarization induced D-Asp release and maintained unchanged glutamate uptake in the hippocampus and endometrial cortex of rats with temporal lobe epilepsy (TLE) model.

Animal Model:	Male rats (24 days old, Sprague Dawley)
Dosage:	75 mg/kg
Administration:	210 min, i.p., measurements were taken at MSO “0”, after 15 min (referred to as MSO “15”, Pilo “15” and MSO + Pilo “15”) and after 60 min (MSO “60”, Pilo “60” and MSO + Pilo “60”, respectively
Result:	Did not affect the hippocampal GS activity and the expression of GS protein for the first 150 min, but significantly decreased the activity during 165-210 min after MSO administration in rats. Additionally, MSO reduced the intensity of CS caused by Pilo administration.

Animal Model:	Hippocampus and enthorhinal cortex of TLE model rats
Dosage:	75 mg/kg
Administration:	i.p., Administration 150 minutes before decapitation
Result:	Markedly reduced D-Asp release evoked by K⁺-induced depolarization and slightly decreased [³H]D-Asp uptake at higher concentrations of [³H]D-Asp in TLE model rats.

分子式

C₅H₁₂N₂O₃S

分子量

180.23

CAS号

15985-39-4

中文名称

L-蛋氨酸磺酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 50 mg/mL (277.42 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.5485 mL	27.7423 mL	55.4847 mL
5 mM	1.1097 mL	5.5485 mL	11.0969 mL
10 mM	0.5548 mL	2.7742 mL	5.5485 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS

Solubility: 100 mg/mL (554.85 mM); Clear solution; Need ultrasonic

纯度： ≥95%

Data Sheet

SDS

产品使用指南

暂无相关参考文献

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器