| 生物活性 |
种属反应性：Human 应用： ELISA, Bioactivity: FACS, Functional assay, Research in vivo 宿主：Human 同种型：IgG4-kappa 表达系统：Mammalian cells Accession：P21980 克隆型号：Monoclonal 纯度：>95% purity as determined by SDS-PAGE. 纯化方式：Protein A/G purified from cell culture supernatant. Zampilimab (UCB-7858) is a monoclonal antibody against transglutaminase 2 (TG2). Zampilimab inhibits TG2 crosslinking transamidation activity with an IC50 of 0.25 nM and a Kd of <50 pM. Zampilimab improves renal fibrosis. |
|---|---|
| 分子量 |
143.48 kDa
|
| CAS号 |
2098280-42-1
|
| 中文名称 |
佐比利单抗
|
| 运输条件 |
Shipping with dry ice.
|
| 储存方式 |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 研究背景 |
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a ~77 kDa protein. Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds.
|
| 种属反应性 |
Human
|
| 宿主 |
Human
|
| 同种型 |
IgG4-kappa
|
| 表达系统 |
Mammalian cells
|
| Accession号 |
P21980
|
| 应用 |
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
|
| 性状 |
Liquid
|
| 保存溶液 |
0.01M PBS pH 7.4
|
| 纯度 |
>95% purity as determined by SDS-PAGE.
|
| 靶标 |
Protein-glutamine deamidase TGM2, TGase II, Heart G alpha(h), Erythrocyte transglutaminase, Protein-glutamine gamma-glutamyltransferase 2, TG(C), Transglutaminase C, Protein-glutamine serotonyltransferase TGM2, tTG, tTgase, Transglutaminase-2, Protein-glutamine noradrenalinyltransferase TGM2, TGM2, TG2, TGase C, Protein G alpha(h), Protein-glutamine histaminyltransferase TGM2, Tissue transglutaminase, hhG alpha(h), G(h), hTG2, Transglutaminase H, Protein-glutamine dopaminyltransferase TGM2, TGC, Isopeptidase TGM2, TGase-2, TGase H, Transglutaminase II
|
| 克隆类型 |
Monoclonal
|
纯度： >95% purity as determined by SDS-PAGE
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