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NOC-5
目录号 : KCM11499 CAS No. : 146724-82-5 纯度 : ≥98%
NOC-5 is a stable nitric oxide (NO)-amine complex that acts as a NO donor. It can release two equivalents of NO in solution under physiological conditions without a cofactor. The half-life of NOC-5 in PBS (pH 7.4) is 93 minutes at 22°C, and it remains relatively stable in alkaline solution (pH ≥10.0).
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1mg
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5mg
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10mg 询价 In-stock
25mg 询价 In-stock

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生物活性

NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors. NOC-5 is able to increase intracellular XIAP and Aven levels, potentially leading to the inhibition of caspase-9 activity following increased mitochondrial permeability.

体外研究

NOC-5 (5-20 μM) can lead to a rapid increase in NO release on the first day in PBS [1].

NOC-5 (100 μM, 24 hours) only activates caspase-3; After NO donor treatment, caspase-3 activity increased. NOC-5 has a pro apoptotic effect in Jurkat cells, but at the same time increases the level of anti apoptotic proteins.

分子式
C6H16N4O2
分子量
176.2
CAS号
146724-82-5
运输条件

Shipping with dry ice.

储存方式
-80°C
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第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
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工作液浓度 mg/ml;

DMSO母液配制方法 mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,

体内配方配制方法μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。

配置后的溶液总体积

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