Digoxin-d3 - CAS:127299-95-0

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Digoxin-d3 (Synonyms:地高辛-d3;12β-Hydroxydigitoxin-d3)

目录号 : KCM10900 CAS No. : 127299-95-0 纯度 : 98%

Data Sheet 产品使用指南

Digoxin-d is intended for use as an internal standard for the quantification of digoxin by GC- or LC-MS. Digoxin is a cardiac glycoside and metabolite of digitoxin that binds to and inhibits the Na/K-ATPase in cardiac tissues in an ATP- and Mg-dependent manner. This inhibition results in loss of the transmembrane Na gradient, which decreases activity of the Na/Ca exchanger, increasing intracellular Ca levels, inotropy, and cardiac force. It increases activity of mitochondrial ATPase and actomyosin ATPase in rat hearts, which is directly correlated with increased myofibrillar contractile strength. In vivo, digoxin also decreases right atrial pressure and increases cardiac output in a canine model of congestive heart failure produced by pulmonary artery constriction. Formulations containing digoxin have been used to treat atrial fibrillation.

规格	价格	是否有货	数量
500μg		In-stock
1mg		In-stock
5mg		In-stock

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Other Forms of Rapamycin:

Ouabain In-stock
(±)17-HETE In-stock
(±)16-HETE In-stock
Digoxin-d3 In-stock
Bufalin In-stock

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生物活性

Digoxin-d3 is deuterium labeled Digoxin. Digoxin is a potent inhibitor of Na+/K+-ATPase, has the potential for arrhythmia and heart failure treatment.

分子式

C₄₁H₆₁D₃O₁₄

分子量

783.95664

CAS号

127299-95-0

中文名称

地高辛-d3；异羟洋地黄毒苷-d3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： 98%

Data Sheet

产品使用指南

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

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动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

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每只动物给药体积

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第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

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计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器