InVivo Plus Anti-Mouse IL17A Antibody (BZN035) is a mouse monoclonal antibody detecting Interleukin-17A in FCM, Neutralization. Suitable for Mouse.
| 生物活性 |
InVivo Plus Anti-Mouse IL17A Antibody (BZN035) is a mouse monoclonal antibody detecting Interleukin-17A in FCM, Neutralization. Suitable for Mouse.
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| 储存方式 |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 研究背景 |
Interleukin-17A (IL17A) is a ~17 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. IL17A is the therapeutic target of secukinumab (Cosentyx).
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| 种属反应性 |
Mouse
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| 宿主 |
Mouse
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| 同种型 |
IgG2a
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| Accession号 |
Q62386
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| 应用 |
FCM, Neutralization
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| 性状 |
Liquid
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| 保存溶液 |
0.01M PBS pH 7.4.
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| 纯度 |
>95% as determined by SDS-PAGE.
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| 内毒素含量 |
< 1 EU/mg
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| 靶标 |
CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, IL17, IL17A, Interleukin-17A
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| 克隆号 |
BZN035
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| 克隆类型 |
Monoclonal
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纯度： >95% as determined by SDS-PAGE
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