5-Hydroxy-1-methylhydantoin - CAS:84210-26-4

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5-Hydroxy-1-methylhydantoin (Synonyms:5-羟基-1-甲基咪唑啉-2,4-二酮)

目录号 : KE9568 CAS No. : 84210-26-4 纯度 : ≥95%

Data Sheet 产品使用指南

NZ-419 is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, NZ-419, a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. NZ-419 a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. NZ-419 inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that NZ-419 may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock

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Other Forms of Rapamycin:

5-Hydroxy-1-methylhydantoin In-stock
[Des-Arg9]-Bradykinin TFA In-stock
[Des-Arg9]-Bradykinin acetate In-stock

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生物活性	NZ-419 is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, NZ-419, a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. NZ-419 a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. NZ-419 inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that NZ-419 may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.
分子式	C₄H₆N₂O₃
分子量	130.103
CAS号	84210-26-4
中文名称	5-羟基-1-甲基咪唑啉-2,4-二酮
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Store at -20˚C