(Des-Arg9)-Bradykinin (Synonyms:[Des-Arg9]-缓激肽)
目录号 : KCM11757 CAS No. : 15958-92-6 纯度 : ≥98%
(Des-Arg)-Bradykinin is an active metabolite of the endogenous vasodilator bradykinin and a peptide agonist of the bradykinin B receptor. It binds to bradykinin B and B receptors (Ks = 1.93 and 8.1 µM, respectively). (Des-Arg)-Bradykinin is formed via carboxypeptidase-mediated cleavage of the bradykinin C-terminal arginine residue in plasma and tissues. It induces relaxation of precontracted isolated endothelium-denuded dog renal artery strips (pD = 8.6). (Des-Arg)-Bradykinin decreases blood pressure in LPS-treated rabbits in a dose-dependent manner.
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5mg
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10mg
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25mg
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50mg
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生物活性

[Des-Arg9]-Bradykinin is a Bradykinin (B1) receptor agonist that displays selectivity for B1 over B2 receptors.

IC50&Target

Bradykinin B1 Receptor (B1R)

体外研究

The B2 receptor mediates the action of bradykinin (BK) and lysyl-bradykinin (Lys-BK), the first set of bioactive kinins formed in response to injury from kininogen precursors through the actions of plasma and tissue kallikreins, whereas the B1 receptor mediates the action of [Des-Arg9]-Bradykinin (des-Arg9-BK) and Lys-des-Arg Arg9-BK, the second set of bioactive kinins formed through the actions of carboxypeptidases on BK and Lys-BK, respectively.

分子式
C44H61N11O10
分子量
904.02
CAS号
15958-92-6
中文名称
[Des-Arg9]-缓激肽
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
动物实验计算换算器
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系客服为您提供正确的澄清溶液配方)
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工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,

体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。

配置后的溶液总体积:

1. 首先保证母液是澄清的;
           2. 一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。