| 生物活性 |
YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration.
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 分子式 |
C19H12N2O2
|
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| 分子量 |
300.31
|
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| CAS号 |
1643120-60-8
|
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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