DBO-83 - CAS:195211-53-1

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DBO-83 (Synonyms:DBO-83 dihydrochloride)

目录号 : KCM12306 CAS No. : 195211-53-1 纯度 : ≥98%

Data Sheet SDS 产品使用指南

DBO-83 is an agonist of nicotinic acetylcholine receptors (nAChRs) with antinociceptive and anti-amnesic activities. It binds to nAChRs in rat cortical membranes with a K value of 4.1 nM in a radioligand binding assay with the α4β2 nAChR partial agonist and α7 nAChR agonist [H]cytisine. DBO-83 dose-dependently increases the latency to paw licking in mice in the hot plate test and reduces the number of abdominal constrictions in mice in the acetic acid abdominal constriction test, effects that can be reduced by the nAChR antagonist mecamylamine . DBO-83 also dose-dependently prevents amnesia induced by mecamylamine, the muscarinic receptor antagonist scopolamine, and the nAChR antagonist dihydro-β-erythroidine in mice in the passive avoidance test.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock

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生物活性

DBO-83 is a brain-penetrant nicotinic acetylcholine receptor (nAChR) agonist. DBO-83 activates peripheral nicotinic acetylcholine receptors to evoke non-stimulated ileum contractions. DBO-83 shows antinociceptive and anti-amnesic activities.

体外研究

DBO-83 (10 µM) exhibits high selectivity towards [3H] - cytisine labeled nicotinic receptors, inhibiting 85% of binding at a concentration of 10 µM and showing no activity towards a group of other receptor types.
DBO-83 can contract the isolated ileum fragment of guinea pigs, with an EC50 of 3.05 μM.

体内研究

DBO-83 (1-20 mg/kg; intraperitoneal injection; (5-7.5 µg per mouse; intraventricular injection) can induce dose-dependent central mediated analgesic effects in mouse hot plate tests.
DBO-83 (5-20 mg/kg; subcutaneous injection) induced dose-dependent analgesic effects in mouse abdominal contraction test.
DBO-83 (10-20 mg/kg; intraperitoneal injection) induced dose-dependent analgesic effects in the paw pressure test in rats. The maximum paw pressure threshold measured 15 minutes after intraperitoneal injection of 20 mg/kg was 104.6 g .
DBO-83 (1-10 mg/kg; intraperitoneal injection) has anti forgetting effects on mice.

Animal Model:

Swiss albino mice in the hot-plate tests (male, 23-30 g)

Dosage:

1 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg (i.p.); 5 µg per mouse; 7.5 µg per mouse (i.c.v.)

Administration:

i.p.; i.c.v.

Result:

Produced a dose-dependent increase in licking latency, peaking 15-30 minutes after injection.
Reached licking latencies of 32.3 sec at 15 minutes, 30.4 sec at 30 minutes, and 25.9 sec at 45 minutes at 10 mg/kg i.p..

Animal Model:

Amnesic mice

Dosage:

1, 5, 10 mg/kg

Administration:

i.p.

Result:

Prevented amnesia induced by Scopolamine, Mecamylamine and dihydro-β-erythroidine.

分子式

C₁₀H₁₃ClN₄^.₂HCl

分子量

297.61

CAS号

195211-53-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

SDS

产品使用指南

Carla Ghelardini, et al. Antinociceptive profile of the new nicotinic agonist DBO-83. Drug development research. 40:,251-258.(1997)

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器