BMS 195614 - CAS:182135-66-6

您当前的位置：

BMS 195614 (Synonyms:BMS 195614/BMS 614)

目录号 : KCM12108 CAS No. : 182135-66-6 纯度 : ≥98%

Data Sheet 产品使用指南

BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (K = 2.5 nM). It antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding.

规格	价格	是否有货	数量
10 mM * 1 mL in DMSO		In-stock
1mg		In-stock
5mg		In-stock
10mg		In-stock
25mg		In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

BMS 195614 In-stock
all-trans-5,6-epoxy Retinoic Acid In-stock
Oxybenzone In-stock
Magnolol In-stock
(+)-Talarozole In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

BMS 195614 is an orally active neutral RARα-selective antagonist with a Ki of 2.5 nM. BMS 195614 restores the expression of Bcl2.BMS 195614 inhibits the transactivation of NF-κB, AP-1 and PPAR.BMS 195614 downregulates the expression of IL-6 and VEGF. BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis.

IC₅₀&Target

BCL2 IL-6

体外研究

BMS 195614 (10-20 μM) can reduce blue light induced phototoxicity and regulate inflammation and angiogenesis in the presence of A2E in RPE cells.
BMS 195614 (6 μM, 24 h) can reverse the anti-inflammatory effects of Vitamin A and RA on LPS activated BV-2 cells releasing IL-6.
BMS 195614 (1 μM, 24 h) can inhibit the migration of MC3T3E1 osteoblast like cells induced by Retinoic acid.

Real Time qPCR

Cell Line:

RPE cells

Concentration:

10 µM

Incubation Time:

Result:

Inhibited NF-κB transactivation, the transactivation of AP-1, the expression of IL-6 and VEGF mRNA.

体内研究

BMS 195614 (2-10 mg/kg, orally, 7 days) showed no or only slight inhibition on overall spermatogenesis in mice.

分子式

C₂₉H₂₄N₂O₃

分子量

448.51

CAS号

182135-66-6

中文名称

BMS 195614/BMS 614

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO: 30 mg/mL (66.89 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2296 mL	11.1480 mL	22.2960 mL
5 mM	0.4459 mL	2.2296 mL	4.4592 mL
10 mM	0.2230 mL	1.1148 mL	2.2296 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

产品使用指南

Fontaine V, et al. RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation. Int J Mol Sci. 2024 Mar 6;25(5):3037.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation

动物实验计算换算器