Monoacylglycerol Lipase Inhibitor 21 (Synonyms:MAGL-IN-17)
目录号 : KCM11859 CAS No. : 1643657-35-5 纯度 : ≥98%
Endocannabinoids such as 2-arachidonoyl glycerol (2-AG; ) and arachidonoyl ethanolamide (AEA; ) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid (CB) receptors. Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of AEA and 2-AG, respectively. MAGL inhibitor 21 selectively binds to MAGL (K = 0.4 µM) and reversibly blocks the enzyme’s activity in mouse brain with an IC value of 0.18 µM. Comparatively, MAGL inhibitor 21 is reported to inhibit FAAH activity in mouse brain with an IC value of 59 µM. This compound does not bind CB or CB receptors and does not inhibit the related serine hydrolases ABHD6 and ABHD12 (Ks > 10 µM). In a mouse model of multiple sclerosis, 5 mg/kg of MAGL inhibitor 21 has been used to ameliorate progression of the disease without producing detrimental CB-mediated effects.
规格 价格 是否有货 数量
5mg
In-stock
10mg
In-stock
50mg
In-stock
100mg
In-stock

Other Forms of Rapamycin:

KKL Med 的所有产品和服务仅用于科学研究,不能被用于人体,兽医,我们也不向个人提供产品和服务。
生物活性

Monoacylglycerol Lipase Inhibitor 21 is an inhibitor for MAGL with a Ki of 0.4 μM. Monoacylglycerol Lipase Inhibitor 21 inhibits mouse MAGL and rat MAGL with IC50 of 0.18 and 0.24 μM. Monoacylglycerol Lipase Inhibitor 21 exhibits anti-inflammatory activity in mouse experimental autoimmune encephalitis models.

IC50&Target

Ki: 0.4 μM (MAGL)

分子式
C26H26O4
分子量
402.48
CAS号
1643657-35-5
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
暂无相关参考文献
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
动物实验计算换算器
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系客服为您提供正确的澄清溶液配方)
+
+
+

计算结果:

工作液浓度 mg/ml;

DMSO母液配制方法 mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,

体内配方配制方法μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。

配置后的溶液总体积

1. 首先保证母液是澄清的;
           2. 一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。