BAY 61-3606 (hydrochloride) - CAS:1615197-10-8

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BAY 61-3606 (hydrochloride)

目录号 : KCM11785 CAS No. : 1615197-10-8 纯度 : ≥98%

Data Sheet 产品使用指南

BAY 61-3606 is an inhibitor of spleen tyrosine kinase (Syk; K = 7.5 nM). It is selective for Syk over Lyn, Fyn, Src, Itk, and BTK (Ks = >4.7 µM for all). BAY 61-3606 inhibits anti-IgE-induced histamine release in isolated human mast cells sensitized with IgE (IC = 5.1 nM), as well as reduces anti-IgM-induced proliferation of isolated mouse splenic B cells (IC = 58 nM). It sensitizes MCF-7 human breast cancer cells to apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) when used at concentrations ranging from 0.31 to 2.5 µM. BAY 61-3606 inhibits passive cutaneous anaphylaxis in rats (ED = 8 mg/kg). It reduces tumor growth in an MCF-7 mouse xenograft model when administered at a dose of 50 mg/kg alone or in combination with TRAIL.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock

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生物活性

BAY 61-3606 (hydrochloride) is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM . BAY 61-3606 (hydrochloride) reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 (hydrochloride) induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 (hydrochloride) sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.

分子式

C₂₀H₁₈N₆O₃^.HCl

分子量

426.86

CAS号

1615197-10-8

中文名称

BAY 61-3606 (hydrochloride)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO: 25 mg/mL (58.57 mM; ultrasonic and warming and heat to 160°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3427 mL	11.7134 mL	23.4269 mL
5 mM	0.4685 mL	2.3427 mL	4.6854 mL
10 mM	0.2343 mL	1.1713 mL	2.3427 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

产品使用指南

暂无相关参考文献

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器