Hydrocortisone 21-hemisuccinate (sodium salt) - CAS:125-04-2

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Hydrocortisone 21-hemisuccinate (sodium salt) (Synonyms:氢化可的松琥珀酸钠;Hydrocortisone hemisuccinate sodium)

目录号 : KCM10835 CAS No. : 125-04-2 纯度 : ≥98%

Data Sheet SDS 产品使用指南

Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC = 6.7 µM for IL-6). It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.

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500mg		In-stock
1g		In-stock

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生物活性

Hydrocortisone 21-hemisuccinate (sodium salt) is an orally active physiological glucocorticoid. Hydrocortisone 21-hemisuccinate (sodium salt) inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone 21-hemisuccinate (sodium salt) can be used for the research of ulcerative colitis (UC).

体外研究

Hydrocortisone 21-hemisuccinate (sodium salt) inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.

Hydrocortisone 21-hemisuccinate (sodium salt) (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.

体内研究

Hydrocortisone 21-hemisuccinate (sodium salt) (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice.

Animal Model:	Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis[1]
Dosage:	30 mg/kg
Administration:	P.o. twice daily for 5 days
Result:	Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group. Increased the body weight.

分子式

C₂₅H₃₃O₈^.Na

分子量

484.51

CAS号

125-04-2

中文名称

氢化可的松琥珀酸钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO: 175 mg/mL (361.19 mM; Need ultrasonic)

H2O : 100 mg/mL (206.39 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0639 mL	10.3197 mL	20.6394 mL
5 mM	0.4128 mL	2.0639 mL	4.1279 mL
10 mM	0.2064 mL	1.0320 mL	2.0639 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

SDS

产品使用指南

[1]. You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器