Anti-IL11 Antibody (X203) (EnX203) 是一种人源的、抗人 IL-11 的 IgG1, κ 型抗体抑制剂。推荐同型对照：Human IgG1 kappa, Isotype Control。
| 生物活性 |
Anti-IL11 Antibody (X203) (EnX203) is a human-derived IgG1, κ type antibody inhibitor, targeting to human IL-11. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control. |
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| IC50&Target |
CDK1 ERK STAT3 IL-11 E-cadherin |
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| 体外研究 |
Anti-IL11 Antibody (X203) (20 μM; 48 h) can effectively inhibit downstream STAT3 phosphorylation induced by IL-11 in Bleomycin induced mouse nucleus pulposus cells.
Western Blot Analysis
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| 体内研究 |
Anti-IL11 Antibody (X203) (20 mg/kg, intraperitoneal injection, twice a week starting from 6 weeks of age, lasting for 2.5 weeks) can improve renal function and prolong the lifespan of Alport syndrome (AS) mouse models.
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| 分子量 |
145.96 kDa
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| 运输条件 |
Shipping with dry ice. |
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| 储存方式 |
Store at -80°C for 2 years. Aliquots should be stored at the same temperature after first use to avoid multiple freeze-thaws |
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| 种属反应性 |
Human
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| 同种型 |
Human IgG1 kappa
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| Accession号 |
P20809
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| 应用 |
ELISA, FACS, Functional assay
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| 基因 ID |
3589 [NCBI]
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| 复溶方法 |
The product can be reconstituted/diluted with sterile PBS or saline.
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| 推荐同型对照抗体 |
Human IgG1 kappa, Isotype Control
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纯度： 98%
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