CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor; IC = 662 μM), displaying a 2-fold improvement in inhibitory potency over anacardic acid . At 30-60 μM, CAY10669 can dose-dependently inhibit histone H4 acetylation in HepG2 cells in vitro.
CAY10669 is an anacardic acid derivative that inhibits histone acetyltransferase PCAF with an IC50 of 662 μM. CAY10669 enhances the SAHA-induced acetylation in HEPG2 cells, exhibits cytotoxicity in zebrafish embryo, promotes transgene expression in CHO-K1 cells.
IC50&Target
PCAF
662 μM (IC50)
分子式
C20H22O4
分子量
326.4
CAS号
1243583-88-1
中文名称
CAY10669
运输条件
Room temperature in continental US; may vary elsewhere.