AG-183 (Synonyms:3-氨基-2,4-二氰基-5-(3'',4'',5''-三羟基苯基)五-2,4-二烯腈;3-氨基-2,4-二氰基-5-(3,4,5-三羟基苯基)五-2,4-二烯腈;酪氨酸磷酸化抑制剂A51)
目录号 : KCM10739 CAS No. : 122520-90-5 纯度 : ≥98%
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC value of 0.8 µM in the human epidermoid carcinoma cell line A431.
规格 价格 是否有货 数量
5mg
In-stock
10mg
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25mg
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50mg
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生物活性

AG-183 is a potent protein tyrosine kinase (PTK) inhibitor. AG-183 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. AG-183 markedly reduces cellular tyrosyl phosphorylation level. AG-183 inhibits both basal and EGF-induced human bone cell proliferation.

分子式
C13H8N4O3
分子量
268.2
CAS号
122520-90-5
中文名称
酪氨酸磷酸化抑制剂A51
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶解性数据
In Vitro: 

DMSO: 20 mg/mL (74.56 mM; Need ultrasonic)

配制储备液
                                           
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
                                                                                                                    
1 mM 3.7281 mL 18.6407 mL 37.2814 mL
5 mM 0.7456 mL 3.7281 mL 7.4563 mL
10 mM 0.3728 mL 1.8641 mL 3.7281 mL
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动物实验计算换算器
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计算结果:

工作液浓度 mg/ml;

DMSO母液配制方法 mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,

体内配方配制方法μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。

配置后的溶液总体积

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           2. 一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。