AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity.
IC50&Target
Ki: 4.9 pM (hCD73)
IC50: 43 pM (Soluble hCD73)
体外研究
AB-680 (AB680) inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8 T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively.
分子式
C20H24ClFN4O9P2
分子量
580.82
CAS号
2105904-82-1
运输条件
Room temperature in continental US; may vary elsewhere.