Jervine - CAS:469-59-0 - KKL Med Inc.

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Jervine (Synonyms:蒜黎芦碱; 11-Ketocyclopamine)

目录号 : KM18665 CAS No. : 469-59-0 纯度 : 98%

Data Sheet 产品使用指南

Jervine (11-Ketocyclopamine)是一种有效的刺猬 (Hh) 抑制剂，IC₅₀ 为 500-700 nM。Jervine 是来自 Veratrum album 的根茎的天然致畸性甾体生物碱。Jervine 具有抗炎和抗氧化特性。

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5mg		In-stock
10mg		In-stock
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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生物活性

Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum album. Jervine has anti-inflammatory and antioxidant properties.

体外研究

Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation.
Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis.

Western Blot Analysis

Cell Line:	HEL and TF1a cells
Concentration:	40 μM
Incubation Time:	6, 12 and 24 hours
Result:	Inhibited Akt phosphorylation.

体内研究

Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.

Animal Model:	Male Sprague Dawley rats (180-200  g)
Dosage:	50, 100, 200 and 400  mg/kg
Administration:	Orally
Result:	Exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.

分子式

C₂₇H₃₉NO₃

分子量

425.60

CAS号

469-59-0

中文名称

蒜黎芦碱；介芬胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 1 mg/mL (2.35 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3496 mL	11.7481 mL	23.4962 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献

•Biochem Biophys Res Commun. 2020 Dec 10;533(3):397-403.

纯度： 98%

Data Sheet

产品使用指南

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Other Forms of Rapamycin:

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