KKL 顾客使用本产品发表的 2 篇科研文献

Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS (Dextran Sulphate Sodium Salt)-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment.

Palmatine exhibits more potent IDO-1 inhibitory activity , which IC₅₀ on rhIDO-1 is 157μM, and on HEK 293-hIDO-1 is 3 μM.

Palmatine (oral administration; 50 or 100 mg/kg, 7 days) has less distortion of epithelium, and fewer infiltrations of inflammatory cells, resulting in significantly lower histopathological scores, it also significantly suppresses the colonic MPO activity.

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