KKL 顾客使用本产品发表的 0 篇科研文献

Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the G_αi1 and β-arrestin-2 signaling pathways with EC₅₀s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart.

Elabela(19-32) (analogue 3) has a K_i of 0.93 nM for binding of radioligand apelin-13[Glp, Nle, Tyr][I].
Elabela(19-32) has an EC₅₀ of 36 nM in HEK293 cells transiently expressing the HA-hAPJ receptor. Elabela(19-32) is slightly less potent than apelin-13 and ELA to elicit receptor internalization.
Elabela(19-32) (0.001 to 0.3 nM) has an EC₅₀ of 1.5 pM in inducing changes in left ventricular developed pressure (LVDP) on the Langendorff perfused isolated rat heart.

Elabela(19-32) (analogue 3) is rapidly metabolized in rat plasma (t_1/2<2 min).

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