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Boric acid is an orally active biochemical reagent. Boric acid serves as a flame retardant for insulation products, and can be used in laundry detergents, cleaning agents and fertilizers. Boric acid is toxic, which can induce chromosomal structural aberrations in lymphocytes, cause lung/liver damage, and induce testicular atrophy and interstitial cell hyperplasia.

Boric acid (up to 1820 μg/plate) does not induce revertant mutations in Salmonella typhimurium strains TA100, TA1535, TA98, and TA1537 with or without metabolic activation.
Boric acid (up to 5000 μg/mL) does not induce mutations in L5178Y mouse lymphoma cells with or without metabolic activation.
Boric acid (up to 1000 μg/mL) can induce chromosome structural aberration in lymphocytes, but will not cause chromosome number aberration or sisters chromatid exchange.

Boric acid (90-270 mg/m³; inhalation; Pregnancy can cause toxicity to pregnant rats, leading to lung/liver damage.
Boric acid (5-20 mg B/kg bw/day; Gavage; Pregnancy days 6-21 and postnatal days 1-28 can lead to a dose-dependent increase in plasma boron levels in offspring; At the highest dose, weight loss and transient umbilical hernia were observed in the offspring, therefore the No Observed Adverse Effect Level (NOAEL) for weight loss in offspring was 10 mg B/kg bw.
Boric acid (2500-5000 ppm; oral; Oral administration of feed; 2 years) has no carcinogenicity, but can cause testicular atrophy and interstitial cell proliferation in high-dose male mice.

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* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)