Topovale - CAS:500214-53-9

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Topovale

目录号 : KE7335 CAS No. : 500214-53-9 纯度 : ≥95%

Data Sheet 产品使用指南

Topovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells.

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5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock
200mg		In-stock

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生物活性	Topovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells.
分子式	C₂₃H₂₃N₃O₅
分子量	421.45
CAS号	500214-53-9
中文名称	ARC-111
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Store at -20˚C