Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.
IC50&Target
IC50: 35 nM (Aldose Reductase)
体内研究
Tolrestat (1.8 mg/kg per day) causes a reversal to normal RBC sorbitol levels diabetic rats. In 21-day diabetic rats, the estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil,
respectively. Either tolrestat or sorbinil inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice.
分子式
C16H14NO3F3S
分子量
357.35
CAS号
82964-04-3
中文名称
托瑞司他;托雷斯萘
运输条件
Room temperature in continental US; may vary elsewhere.